New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more.
Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.
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Table of Contents
1. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis2. New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases
3. Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase
4. Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses
5. Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces
6. Kinetics and Mechanism for Reactions of Enzyme Pieces
7. Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase
8. Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase
9. Innovative and emerging modalities of EGFR kinase inhibitors
10. Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases
11. Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase
12. Probing the mechanism of flavin action in the oxidative decarboxylation catalyzed by salicylate hydroxylase
13. Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase
14. The Role of Protein Motions in Catalysis
15. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis
16. Adaptation of Transient State Methods to Reveal the Mechanism of Mammalian Dihydropyrimidine Dehydrogenase
17. Charge Resonance in Enzyme Redox Reactions
18. Motions and Allostery in Human Glucokinase
19. Kinetic Dissection of CRISPR CAS-9
20. Oxygenase PLP Chemistry
21. Electron bifurcating flavoproteins
