Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers, and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.
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Table of Contents
Section 1 The liver sinusoid General concepts 1. The unique architecture of the hepatic sinusoid 2. Sinusoidal cells interactions from soluble factors to exosomes 3. Sinusoidal cells and liver immunology 4. Microscopic imaging of the hepatic sinusoid 5. The liver sinusoid at single cell level 6. Advanced models to study the liver sinusoid 7. Aging and the liver sinusoid
Section 2 The liver sinusoid in acute liver injury 8. Drug-induced liver injury 9. Ischemia-reperfusion injury and liver regeneration 10. Acute bacterial and viral infections
Section 3 The liver sinusoid in chronic liver disease 11. NAFLD and NASH 12. Chronic viral infection 13. Alcoholic liver disease 14. Portal hypertension 15. Liver fibrosis 16. Acute on chronic liver failure 17. Liver cancer 18. Cholestatic diseases
Section 4 The liver sinusoid in other vascular diseases 19. Portal vein thrombosis 20. Sinusoidal obstructive syndrome 21. Budd Chiari syndrome
Section 5 Liver sinusoidal cells in the diagnosis and treatment of liver diseases 22. Role of liver sinusoidal endothelial cells 23. Role of Kupffer cells and other immune cells 24. Role of hepatic stellate cells
Authors
Jordi Gracia-SanchoJordi Gracia-Sancho is the Chief of the Liver Vascular Biology Research Group at the IDIBAPS Research Institute - Hospital Cl�nic de Barcelona, Associate Researcher at the Department of Visceral Surgery and Medicine - University of Bern, & Scientific Director of the Spanish Research Consortium on Liver & Digestive Diseases (CIBEREHD).
He graduated in Biochemistry receiving undergraduate research training in basic hemochromatosis at the London Metropolitan University, pursued pre-doctoral studies in basic portal hypertension at the University of Barcelona Medical School, and post-doctoral training at the Center for Excellence in Vascular Biology - Harvard Medical School & Brigham and Women's Hospital. In 2012 he obtained the "Ram�n y Cajal� Spanish tenure-track position and then promoted to his current senior position.
Jordi's research focuses on liver vascular pathobiology with special interest in the role of sinusoidal cells, and their interactions, in acute and chronic liver diseases, and in aging. He (co-)authored more than 125 peer-reviewed original papers and reviews, and currently serves as Associate Editor for the Journal of Hepatology. In addition, he is invited professor in different universities within Spain and Europe and co-leads diverse educational initiatives including the LiverSeminars Program (www.liverseminars.eu), the 2018 EASL-Basic School of Hepatology, the 2020 APASL-Symposium on Regression of Portal Hypertension, the 2020 AASLD-Symposium on Senescence and Liver Diseases, the 2021 EASL-Symposium on Sinusoidal Cells in Liver Diseases and the 2023 AMH-Irwin Arias Symposium.
Prof Gracia has been invited speaker in different national and international conferences, including the annual meetings of the European, American and Asia-Pacific associations of Hepatology. He has been member of the Scientific Committee of the Spanish Association for the Study of the Liver (AEEH) and the Steering Committee of the Portal Hypertension Special Interest Group of the American Association for the Study of Liver Diseases (AASLD). He is now member of the Governing Board of AEEH, the Basic Research Committee of AASLD and the Baveno Cooperation Steering Committee. In 2016 he received the Emerging Leader Award from the European Association for the Study of the Liver (EASL). He served as Scientific Secretary of the International Society for Hepatic Sinusoidal Research (ISHSR) from 2017-2022, being now the President-Elect of this Society.
