Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease.
Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.
Table of Contents
1. Introduction2. SSNMR: Methods and Applications3. Cryo-EM: methods and applications4. Amyloid-beta oligomers and fibrils5. a-Synuclein oligomers and fibrils6. TDP-43 oligomers and fibrils7. Tau oligomers and fibrils8. Prion oligomers and fibrils9. IAPP oligomers and fibrils10. Example and effects of post-translational modifications in amyloid structure (Part I)11. Effect of post-translational modifications in Amyloid structure (part II)12. Chemical modifications and amyloid structure13. Energy landscape of amyloid formation14. Computational studies of amyloid fibrils15. Computational models of amyloid fibrils
Authors
Vijay Kumar Assistant Professor, Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, India.
Vijay Kumar, Ph.D. has been Assistant Professor in Amity University, since 2018. He obtained his PhD in Biophysics from All India Institute of Medical sciences, New Delhi, India and did his Postdoctoral training from the university of Massachusetts Medical school, Massachusetts, USA. His postdoctoral research was focused on folding and aggregation studies of proteins, SOD1 and TDP-43 involved in motor neuron disease, ALS and FTD. Back to India, he worked as a Principal Investigator under DST-SERB Young Scientist Scheme in Jamia Millia Islamia (A central university), New Delhi. His present research interests focus on the area of folding, misfolding and aggregation of proteins and the role of toxic RNA species involved in the Neurodegenerative Diseases. Dr. Kumar is a member of the Protein Society, Indian Biophysical Society (IBS), Indian Academy of Neurosciences (IAN), and the International society for Neurochemistry (ISN). He had a Junior Research Fellowship/Senior Research fellowship (SRF) from Council of Scientific and Industrial Research (CSIR), New Delhi, India and a DAAD Fellowship , Germany.
Oxana V. Galzitskaya Head of Laboratory of Bioinformatics and Proteomics Institute of Protein Research Russian Academy of Sciences Pushchino, Russia.
Dr Galzitskaya is a specialist in molecular biology, biophysics, and bioinformatics, and author of over 200 scientific papers, including 11 articles in the Atlas of Science. She is a member of the Editorial Board of the journals "Current Protein and Peptide Science", "The Open Biochemistry Journal", "The Open Bioinformatics Journal", "The Open Journal of Biochemistry", "Austin Biometrics and Biostatistics", "World Journal of Biological Chemistry" until 2017, "Scientific Pages of Alzheimer's Disease & Dementia", and editor of the "Journal of Alzheimer's Disease" from 2015-2019. She is also member of the expert council of the Russian Science Foundation in biology and the scientific council of the Institute of Protein Research of the Russian Academy of Sciences. Her research interests include folding and misfolding of proteins resulting in the development of pathologies in the body of an aging person (including the analysis and formation of fibrils in Alzheimer's), systems biology and bioinformatics, mechanisms of aging and protein levels, early stages of Alzheimer's, and the creation of antimicrobial peptides. She is currently Head of Laboratory of Bioinformatics and Proteomics at the Russian Academy of Sciences in the Institute of Protein Research.
