Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs), which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for drugs. Nano-drug delivery has emerged as a promising technology that results in early detection and better treatment of various cancers. The approved nanoparticles currently used in cancer treatment strategies include liposomes, dendrimers, polyplexes, solid lipid nano-carriers, etc. These nanocarriers can potentially provide a quick, safe, and cost-effective method in cancer therapy and management.
This book presents thirteen chapters that cover cancer nanotherapeutics for various cancers. The reference covers lung, breast, cervical, ovarian, colon, prostate, and head and neck cancers. Each chapter reviews advanced data from existing and ongoing clinical research and major regulatory considerations. A list of scientific references for further reading supplements every chapter. Readers will be able to understand recent advances and challenges faced by researchers in cancer nanomedicine.
This reference book will greatly benefit undergraduate and postgraduate students, oncologists, pharmacists, and researchers involved in nanomedicine and nano-drug delivery.
This book presents thirteen chapters that cover cancer nanotherapeutics for various cancers. The reference covers lung, breast, cervical, ovarian, colon, prostate, and head and neck cancers. Each chapter reviews advanced data from existing and ongoing clinical research and major regulatory considerations. A list of scientific references for further reading supplements every chapter. Readers will be able to understand recent advances and challenges faced by researchers in cancer nanomedicine.
This reference book will greatly benefit undergraduate and postgraduate students, oncologists, pharmacists, and researchers involved in nanomedicine and nano-drug delivery.
Table of Contents
Chapter 1 Cancer Biology- Introduction
- Cancer Incidence and Etiology
- Histopathology
- Cancer Genetics
- Protooncogene
- Antioncogenes
- Apoptosis Regulator Gene
- Dna Repair Gene
- Tumour Vasculature
- Hallmarks to Cancer
- Biomarkers for Cancer: What Are They and How Do They Help?
- Some Other Important Cancer Biomarkers
- Metabolic Transformation in Cancer
- Cell Cycle-Targeted Cancer Therapies
- Apoptosis and Cancer
- Stem Cells Targeted Cancer Therapy
- Pluripotent Stem Cells (Pscs) in Cancer Treatment
- Adult Stem Cells in Cancer Treatment
- Cancer Stem Cells (Cscs) in Cancer Treatment
- Tumour Suppressor Genes in Cancer
- P53
- Retinoblastoma (Rb)
- Pten (Phosphatase and Tensin Homologue)
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Farhan Mazahir, Anchal Pathak, Ujala Gupta and Awesh K. Yadav
- Introduction
- Polymeric Ncs
- Polymeric Ncs: Polycaprolactone (Pcl) Ncs
- Polymeric Ncs: Poly (Lactic-Co-Glycolic Acid) (Plga) Nps
- Polymeric Ncs: Polyplexes
- Polymeric Ncs: Chitosan (Chn) Nps
- Micelles (Mcs)
- Micelles (Mcs): Niosomes
- Nanostructured Lipid Carriers (Nlcs)
- Inorganic Ncs (Incs)
- Inorganic Ncs (Incs): Iron-Based Ncs
- Inorganic Ncs (Incs):Au - Based Ncs
- Inorganic Ncs (Incs): Gadolinium (Gd) Based Ncs
- Mesoporous Silica-Based Nps (Msnps)
- Msnps and Tumor Targeting
- Msnps Based Nps in Photothermal Therapy (Ptt)
- Msns in Gene Therapy
- Other Carriers for Ptt
- Ag-Based Ncs
- Copper Sulfide-Based Ncs
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- B. Patil, A. Tiwari, S.P. Pandey, T. Shukla and N. Upmanyu
- Introduction
- Cancer
- Nanocarriers
- Importance of Nano-Carriers in the Management of Cancer
- Different Approaches to Surface Modification of Nanoparticles With Their Significance in the Management of Cancer
- Surface Modification With Polyethylene Glycol(Peg)
- Use of Pegylated Di-Bock Polymers for the Formation of Nanocarrier
- Use of Pegylated Tri-Block Polymers for the Formation of Nanocarriers
- Pegylation of Already Formed Vesicles
- Formulation of Stimuli-Sensitive Nanocarrier
- Ph-Sensitive Nanocarriers
- Temperature Sensitive Nanocarrier
- Surface Modification Using Different Ligands
- Modification of Nano-Carrier/Nanoparticles Surface With Transferrin
- Modification of Nano-Carrier/Nanoparticles Surface With Folate
- Modification of Nano-Carrier/Nanoparticles Surface With Aptamers
- Modification of Nano-Carrier/Nanoparticle Surface With Peptides and Monoclonal Antibodies
- Modification of Nano-Carrier Surface With Anisamide
- Modification of Nano-Carrier Surface With Cell-Penetrating Peptides
- Other Approaches to Surface Modification
- Light-Sensitive Nano Preparation
- Ultrasound-Responsive Drug Delivery Systems
- Magnetic Field-Sensitive Nano Preparation-
- Role of Surface-Modified Nano-Carriers in the Diagnosis of Different Types of Cancer
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgment
- References
- Meghna A. Singh, Azmi Khan, Tarani P. Shrivastava, Firdos Khan, Ajay Sharma and Madhu Gupta
- Introduction
- Physicochemical and Biological Barriers in Tumor Targeting
- Need of Nano-Formulations in Cancer Treatment
- Biodegradable and Non-Biodegradable Polymers
- Biodegradable Polymers
- Mechanism of the Breakdown of Biodegradable Polymers
- Examples of Biodegradable Polymers
- Non-Biodegradable Polymers
- Examples of Non-Biodegradable Polymers
- Targeted Delivery for Smn in the Management of Cancer
- Passive Targeting
- Active Targeting
- Challenges for Smns in Cancer Drug Targeting
- Clinically Approved/ Patented Nano-Formulations
- Conclusion and Future Prospective
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- Reference
- Ashish Garg, Vijay Sagar Madamsetty, Sumel Ashique, Vinod Gauttam and Neeraj Mishra Introduction
- Prostate Cancer Nanocarriers & Nanotechnology
- Routes of Drug Delivery to the Prostate
- Systemic Route
- Locoregional Routes
- Intraprostatic Route
- Vas Deferens
- Transrectal
- Nanoparticles System for Prostate Targeting Classifications
- Prostate Cancer and Liposomal Nanoparticles
- Systems of Polymeric Nanoparticles for Cancer Treatment
- System of Carbon-Based
- Dendrimeric Device
- Quantum Dot Platform
- System of Gold Nanoparticulate
- Platform for Metallic Nanoparticle
- Prostate Cancer Diagnosis and Nanotechnology Approach
- Prostate Cancer Fluorescence Diagnosis Using Nanotechnologies
- Targeted Psa Nanoprobe for Imaging Prostate Cancer
- Prostate-Specific Membrane Antigen (Psma) Nanoprobes for Imaging Prostate Cancer ..
- Recent and Ongoing Clinical Trials for Prostate Cancer Treatment
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgments
- References
- Sidhartha S. Kar, Arghya Kusum Dhar and Shvetank Bhatt Introduction
- Conventional Diagnosis and Treatment of Breast Cancer
- Limitations of the Current Breast Cancer Treatments
- Nanodelivery Systems in the Treatment of Breast Cancer
- Ideal Characteristics of Nps
- Types of Nanocarriers
- Lipid-Based Nanocarriers
- Features of Lipid-Based Nanocarriers
- Liposomes
- Advantages
- Disadvantages
- Solid Lipid Nanoparticles (Slns)
- Advantages
- Disadvantages
- Nanostructured Lipid Carriers (Nlcs)
- Advantages
- Disadvantages
- Lipid-Polymer Hybrid Nanoparticles
- Advantages
- Disadvantages
- Nanoemulsions
- Advantages
- Disadvantages
- Example
- Polymeric Nanoparticles
- Dendrimers
- Polymeric Micelles
- Polymer-Drug Conjugates
- Inorganic Nanoparticles
- Gold Nanoparticles (Aunps)
- Quantum Dots
- Carbon-Based Nanoparticles
- Carbon Nanotubes
- Carbon Dots
- Fullerene and Graphene
- Magnetic Nanoparticles
- Superparamagnetic Iron Oxide (Spio)
- Silica Nanoparticles
- Titanium Oxide Nanoparticles
- Other Inorganic Nanoparticles
- Antibody-Conjugated Nanoparticles
- Exosomes as Nanocarrier
- Virus-Based Nps "
Author
- Neeraj Mishra
-Ashish Garg
