Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
Table of Contents
- An Overview on Colonic Diseases
- Colonic disease targeting strategies
- Nanocarriers for the colonic diseases
- Applications of nanocarriers in colon targeting
- Polymeric nanoparticles in colon targeting
- Polymersomes in colon targeting
- Polymeric micelles in colon targeting
- Solid lipid nanoparticles in colon targeting
- Nanostructured lipid carriers in colon targeting
- Liposomes in colon targeting
- Carbon-based nanomaterials in colon targeting
- Gold nanoparticles in colon targeting
- Supramagnetic iron oxide nanoparticles for colon targeting
- Magnetic triblock copolymer nanoparticles in colon targeting
- Dendrimer nanoparticles for colon targeting
- Mesoporous silica nanoparticles in colon targeting
- Redox nanoparticles in colon drug targeting
- Protein and peptides-based nanoparticles in colon targeting
- Hybrid nanoparticles in colon targeting
- Polysaccharides Based nanocarriers in colon targeting
- Nanocrystals based approach in colon targeting
- Nano-based enema’s for colon targeting
- Exosomes in colon targeting
- Nano carriers in Inflammatory Bowel Disease and Colorectal Cancer
- Self-Nano Emulsifying Drug Delivery Systems in Colon Targeting
- Pre-clinical and clinical status of different nanocarriers for colon targeting
- Regulatory issues and toxicological concerns related to nanocarriers
