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Nanocarriers for Drug-Targeting Brain Tumors. Micro and Nano Technologies

  • Book

  • June 2022
  • Elsevier Science and Technology
  • ID: 5527399

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and� their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems.

Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting.

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Table of Contents

Part A Anatomy and physiology of the brain
1. An overview of the anatomy and physiology of the brain
2. Blood-brain barrier and central nervous system drug delivery: Opportunities and challenges

Part B Pharmacological and clinical problems
3.Challenges in targeting to brain and brain tumors
4. Potential targeting sites in brain and brain tumors
5. Drug resistance problems in chemotherapy

Part C Introduction and biomedical applications of nanocarriers
6. An overview on nanocarriers
7. Biomedical applications of nanocarriers in brain tumor targeting

Part D Lipophilic nanocarriers
8. Solid lipid nanoparticle-based drug delivery for targeting brain tumors
9. Nanostructured lipid carriers as an alternative carrier with high drug loading for targeting to brain tumors
10. Design, development, and mechanism of liposomes in drug targeting to brain tumors
11. Niosomes based drug delivery in targeting brain tumors
12. Nanoemulsions as effective carriers for targeting brain tumors

Part E Polymeric nanocarriers
13. Mechanism of polymeric micelles for drug targeting to brain tumors
14. Dendrimers as carriers for active targeting of brain tumors
15. Multifunctional polymeric nanocarriers for targeting and treatment of brain tumors
16. Polymersomes for targeting to brain tumors

Part F Metallic nanocarriers systems
17. Development and applications of gold nanoparticles for drug targeting to brain tumors
18. Gold nanoparticles in cancer theranostics
19. Targeting of silver nanoparticles to brain tumors

Part G Hybrid nanocarriers
20. Hybrid nanoparticles to cross the blood-brain barrier
21. Targeting of lipid-polymer (hybrid) nanoparticles to brain tumors
22. Nano-enabled systems for neural tissue regenerative applications
23. Multifunctional liposome-quantum dot hybrid nanocarriers for drug targeting to brain tumors
24. Drug-loaded nanoclusters for brain targeting
25. Nano-enabled platforms for tropical diseases affecting the CNS
26. Phytoconstituents in brain delivery using nanodrug delivery
27. Multifunctional nanocarrier systems targeting brain tumors: A review

Part H Future directions and toxic concerns
28. Expert opinion on current challenges and future directions related to nanocarriers for drug targeting to the brain
29. Biological nanodrugs for brain targeting

Authors

Lalit Kumar Assistant Professor, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India. Lalit Kumar is an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, Bihar, India. His area of research includes the development of nanocarriers for drug-targeting tumor cells in the colon, brain, breast, and lungs. Yashwant Pathak Professor and Associate Dean, Faculty Affairs, College of Pharmacy, University of South Florida, Tampa, USA. Yashwant Pathak is a Professor and Associate Dean for faculty affairs at the Taneja College of Pharmacy at the University of South Florida, Tampa, USA. Prof. Pathak is also an Adjunct Professor at the Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia. His area of research is in health care education, nanotechnology, drug delivery systems, and nutraceuticals.