Taurine, or 2-aminoethanesulfonic acid, is one of the most abundant sulfur-containing amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement.
Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements.
Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements.
Topics covered in this reference include
- Synthesis of taurine and its dietary sources
- The Role of taurine in mitochondrial health
- Taurine as a neurotransmitter
- Beneficial effects of taurine in physiological systems such as the reproductive system, renal system, and the gastrointestinal tract
- Hepatoprotective and anti-inflammatory properties of taurine
- The anti-aging promise of taurine supplementation
- Role of taurine supplementation in obesity
Table of Contents
Chapter 1 Taurine: Synthesis, Dietary Sources, Homeostasis, and Cellular Compartmentalization- Introduction
- Taurine Synthesis, Dietary Sources, and Cellular Compartmentalization
- Lessons Learned from Taurine-Transporter Knockout Experimental Models
- Conclusion
- References
- Introduction
- Taurine in the Basic Mitochondrial Structures
- Taurine Regulates Mitochondria-Facilitated Oxidants Production
- Taurine and Cellular Energy Metabolism
- Taurine and Cellular Calcium Homeostasis
- Taurine Therapy in Mitochondria-Linked Pathologies
- Taurine and Human Mitochondrial Cytopathies
- Conclusion
- References
- Introduction
- The Pleiotropic Roles of Taurine in the Central Nervous System (Cns)
- Effects of Taurine on Stroke and Brain Ischemia
- Taurine and Traumatic Brain Injury
- Taurine and Hepatic Encephalopathy
- The Long Story of Using Taurine in Seizure and Epilepsy
- Role of Taurine in Neurodegenerative Disorders
- Taurine in Alzheimer’S Disease (Ad)
- Taurine and Parkinson’S Disease
- Huntington’S Disease: the Therapeutic Potential of Taurine
- Conclusion
- References
- Introduction
- Taurine and the Cardiovascular System
- Molecular Mechanisms of Taurine Action in Cardiomyocytes
- Myocardial Infarction and Ischemia-Reperfusion Injury
- Heart Failure
- Role of Taurine in the Management of Arrhythmia
- Taurine and Other Cardiovascular Disorders
- Conclusion
- References
- Introduction
- Taurine and the Liver
- Taurine and Liver Fibrosis
- Taurine and Alcohol-Induced Liver Injury
- Taurine and Non-Alcoholic Fatty Liver
- Taurine Prevents Xenobiotics-Induced Liver Injury: a Focus on Mitochondrial-Dependent Mechanisms
- Conclusion
- References
- Introduction
- The Relevance of Mitochondria-Originated Oxidative Stress and Aging
- Age-Associated Oxidative Stress to Mitochondrial Structure and Function
- The Role of Uncoupling Proteins and Ros Formation in Aging: Noninvestigated Role of Taurine
- Impaired Extra-Mitochondrial Biomolecules Turn-Over and Aging
- Participation of Mitochondria in Age-Related Sub-/In- Fertility? .
- Ahr- Associated Aging: Ahr-Mitochondria Crosstalk
- Conclusion
- References
- Introduction
- Mechanisms of Taurine Action in the Skeletal Muscle
- Taurine Regulates Ion Channels in the Skeletal Muscle
- Taurine is Actively Incorporated in the Synthesis of Skeletal Muscle Mitochondrial Components
- Evidence of the Positive Effect of Taurine O Muscular Disorders Linked With Mitochondrial Impairment
- The Role of the Autophagy-Lysosome System in Muscle Atrophy
- Conclusion
- References
- Introduction
- The Critical Role of Cellular Mitochondria and Energy Metabolism in the Kidney
- Effect of Taurine on the Kidney: Focus on Mitochondrial-Related Pathologies
- Taurine and Xenobiotics-Induced Renal Injury: Relevance to Mitochondrial Impairment
- Effects of Taurine on Mitochondria-Connected Pathologies in Some Common Renal Disorders
- Renal Ischemia-Reperfusion Injury
- Nephrolithiasis
- Cholestasis/Cirrhosis-Induced Renal Injury
- Conclusion
- References
- Taurine in the Digestive System: Absorption, Metabolism, and Excretion
- Taurine and Gi Disorders
- Conclusion
- References
- Introduction
- The History of Taurine/Hypotaurine on Reproductive Parameters
- Ameliorative Role of Tau on Xenobiotics-Induced Gonadotoxicity, Spermatotoxicity, and Steroidogenotoxicity
- Remarkable Point
- Taurine and Apoptosis Through Mitochondrial Function and Inflammatory Responses
- Taurine and Autophagy in the Reproductive System
- Taurine Mitigates Oxidative Stress Via Mitochondrial-Dependent and Independent Pathways: With An Eye to Steroidogenesis and Spermatogenesis
- Xenobiotics-Induced Er Stress and Mitochondrial Dysfunctionality Instigates Inflammation: the Ameliorative Role of Taurine
- Conclusion
- References
- Introduction
- Types of Adipocytes and Their Relevance to Energy Metabolism and Storage
- The Central Modulators in Obesity: the Role of Taurine
- Mitochondria, Adipocytes, and Obesity
- Ameliorative Role of Taurine in Adipose Tissues’ Energy Metabolisms
- The Anti-Obesity Role of Tau Through Mitochondrial Function Improvement
- The Effects of Taurine Combination Therapy in Adipose Tissue
- Conclusion
- References
- Introduction
- The Importance of Enhancing Taurine Bioavailability in Specific Organs
- Novel Strategies for Targeting Mitochondria
- Conclusion
- References
Author
- Reza Heidari
-M. Mehdi Ommati
