Gene synthesis is the scientific method for generating or producing artificial genes. Gene synthesis refers to the process by which genes are created using various ways aimed at assembling and constructing genes from nucleotides. Nucleotide is an essential building block in the process of creating nucleic acid.
In reality, RNA and DNA are made up of lengthy sequences of nucleotides. These chemicals are made up of sugar molecules coupled to a phosphate and a nitrogen-containing base. The gene synthesis technique enables scientists and researchers to precisely specify and tailor the desired sequence.
The increase in the geriatric population, rise in the incidence of chronic illnesses, cost-effective treatment, and increase in demand for novel vaccines are some of the primary factors anticipated to drive the gene synthesis market growth. Because of the rising prevalence of infectious diseases around the world, the demand for effective treatments and vaccines has increased, prompting researchers and scientists to accelerate their research efforts and produce effective treatment options for diseases such as cancer and tumors. Certain illnesses can be effectively treated with chemical drugs and biological treatments, such as gene therapy. The application of genomics has enhanced the treatment of endemic and infectious diseases. It also allows us to better understand new drug resistance and identify possible targets for vaccines and new medicines. Gene therapy has piqued the interest of many researchers for the treatment of infectious diseases since it can be treated with recombinant DNA technology, DNA & RNA ribozyme, and single chain antibodies.
The rapid evolution of the technology involved in gene therapy necessitates increased skill work and experienced individuals for the insertion of genes or the execution of gene therapy procedures in patients. Most healthcare professionals’ inability to carry out the therapy may have a negative impact on the gene synthesis market throughout the forecast period.
Increase in government support for the research involving synthesis of new genes, rise in therapy efficiency, and growth in research and development by the researchers, scientists, and pharmaceutical & biotechnological companies is expected to drive the market growth in the future. In addition, the market growth is expected to boost in the coming years owing to reimbursement policies so that every individual can benefit from the treatment of new technologies developed. This contributes to the rise in the gene synthesis market.
The COVID-19 pandemic has had an impact on the gene synthesis industry, both positively and negatively. During the initial phase of the pandemic, the coronavirus 2019 (COVID-19), which has caused significant challenges in the supply of materials, production, and logistical operations, significantly impacted the cell and gene therapy (CGT) business. When the COVID-19 pandemic began, most businesses and research initiatives around the world suspended operations, reducing market demand for gene synthesizers and their use in laboratories.
The spread of the COVID-19 pandemic has aided the gene synthesis business by creating enormous growth possibilities. The topic of gene synthesis is being investigated for undiscovered potential, which is supporting the growth of the market in terms of revenue creation.
The key players profiled in this report include Genscript Biotech Corporation, Thermo Fisher Scientific, Inc., Brooks Automation, Inc., Boster Biological Technology, Twist Bioscience Corporation, Danaher Corporation, Biomatik Corporation, ProteoGenix, ProMab Biotechnologies, Inc., and OriGene Technologies, Inc.
The gene synthesis market is segmented on the basis of method, end user, and region. As per method, the market has been divided into solid phase synthesis, PCR-based enzyme synthesis, and CHIP-based DNA synthesis. By end user, the market has been classified into academic and research institutes, biotech and pharmaceutical companies, diagnostic laboratories, and other. Region wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Key Benefits For Stakeholders
- This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the gene synthesis market analysis from 2021 to 2031 to identify the prevailing gene synthesis market opportunities.
- The market research is offered along with information related to key drivers, restraints, and opportunities.
- Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
- In-depth analysis of the gene synthesis market segmentation assists to determine the prevailing market opportunities.
- Major countries in each region are mapped according to their revenue contribution to the global market.
- Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
- The report includes the analysis of the regional as well as global gene synthesis market trends, key players, market segments, application areas, and market growth strategies.
Key Market Segments
By Method
- Solid Phase Synthesis
- PCR Based Enzyme Synthesis
- CHIP Based DNA Synthesis
By End User
- Biotech and Pharmaceutical Companies,
- Diagnostic Laboratories
- Academic and Research Institutes,
- Other
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- UK
- Germany
- France
- Spain
- Italy
- Rest of Europe
- Asia-Pacific
- China
- India
- Japan
- South Korea
- Australia
- Rest of Asia-Pacific
- LAMEA
- Brazil
- Saudi Arabia
- UAE
- South Africa
- Rest of LAMEA
Key Market Players
- Brooks Automation, Inc.
- Boster Biological Technology
- Twist Bioscience
- Codex DNA
- Biomatik
- promab biotechnologies, inc.
- Thermo Fisher Scientific, Inc.
- Genscript Technology
- Integrated DNA Technologies, Inc.
- OriGene Technologies, Inc.
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Table of Contents
Executive Summary
According to the report titled, “Gene Synthesis Market," the gene synthesis market was valued at $1,110 million in 2021, and is estimated to reach $5,979 million by 2031, growing at a CAGR of 18.4% from 2022 to 2031.Gene Synthesis is a biological approach that is used to create artificial genes in a laboratory setting. This approach allows for the alteration and construction of DNA sequences, which opens up a world of possibilities in biological functionality. Furthermore, because artificial gene synthesis does not require template DNA, the DNA sequences may be produced in the laboratory. It consists of two major steps: the creation of oligonucleotide fragments and their connection using DNA assembly methods.
The chemical synthesis of DNA strands base by base is referred to as gene synthesis. Gene synthesis, unlike DNA replication in cells or via Polymerase Chain Reaction (PCR), does not require a template strand. Rather, gene synthesis entails adding nucleotides to a single-stranded molecule step by step, which then acts as a template for generating a complementary strand. The fundamental technology upon which the field of synthetic biology has been built is gene synthesis.
There is a rapid spread of diseases among the population as people's lifestyles change. The growing number of chronic diseases such as cancer, cardiovascular disease, HIV, gastrointestinal disorders, and many others contribute to the growth of the gene synthesis industry. Utilization of gene synthesis in the treatment of chronic diseases with increased research and development and advanced technologies developed in gene synthesis is expected to boost the market growth further. Also, developed innovations and enhanced efficacy and safety of the produced genes with improved demands from the medical sector has further boosted market growth. Increased gene synthesis with considerable use of genes in the production of novel vaccines, as well as increased funding from corporations, will drive market expansion throughout the forecast period.
Growing emphasis on clinical research to discover biological systems at the fundamental molecular level is expected to stimulate demand for gene synthesis in the coming years. Life science research is expanding as a result of recent technical developments that have resulted in the production of well-designed products and services such as molecular separation, microchip-based gene synthesis, and protein purification. Gene synthesis has long been recognized as a more efficient and cost-effective alternative to classic cloning and mutagenesis techniques. These reliable and time-efficient solutions are pushing the industry and encouraging federal funding in industrialized nations for countless academic research projects. For instance, in March 2018, SynbiCITE, a National Innovation and Knowledge Centre situated in the UK that uses synthetic biology, said that they had earned roughly US$17.6 thousand in grants and US$318.5 thousand in private investment. Furthermore, SynbiCITE has provided national assistance to Synbio, a biotech business, in order to expand the use of gene synthesis. All of these factors will contribute to the worldwide market's growth.
The growing use of personalized medications has opened up opportunities for genomics, which requires error-free gene sequencing at a low cost and in a short period of time, which may provide substantial prospects for the industry in the future. The increasing use of gene synthesis in healthcare is one of the factors projected to drive the gene synthesis market. These are some of the factors that might lead to significant market opportunities in the coming years.
The gene synthesis market is segmented on the basis of method, end user, and region. On the basis of method, the market is classified into solid phase synthesis, PCR based enzyme synthesis, and chip based DNA synthesis. As per end user, it is divided into academic and research institutes, biotech and pharmaceutical companies, diagnostic laboratories, and other. Region wise, it is analyzed across North America (the U.S., Canada, and Mexico), Europe (the UK, Germany, France, Italy, Spain, and rest of Europe), Asia-Pacific (China, India, Japan, Australia, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, UAE, and rest of LAMEA).
The key players profiled in the study include Genscript Biotech Corporation, Thermo Fisher Scientific, Inc., Brooks Automation, Inc., Boster Biological Technology, Twist Bioscience Corporation, Danaher Corporation, Biomatik Corporation, ProteoGenix, ProMab Biotechnologies, Inc., and OriGene Technologies, Inc. The players in the market are actively engaged in the adoption of various strategies such as acquisitions, product launches, and expansion to remain competitive and gain advantage over competitors in the market.
Key Market Insights
- On the basis of method, the solid phase synthesis segment had a dominating market share in 2021, and PCR based enzyme synthesis is estimated to be the fastest growing segment during the forecast period.
- On the basis of end-user, the academic and research institutes segment is accounted to have a dominating market share in 2021 and it is anticipated to show the fastest growth during the forecast period.
- Region wise, North America was the highest revenue contributor in 2021 and Asia-Pacific is anticipated to show the fastest growth during the forecast period.
Companies Mentioned
- Brooks Automation, Inc.
- Boster Biological Technology
- Twist Bioscience
- Codex DNA
- Biomatik
- promab biotechnologies, inc.
- Thermo Fisher Scientific, Inc.
- Genscript Technology
- Integrated DNA Technologies, Inc.
- OriGene Technologies, Inc.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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