Proteases Market Report 2025

The proteases market size has grown strongly in recent years. It will grow from $3.4 billion in 2024 to $3.63 billion in 2025 at a compound annual growth rate (CAGR) of 6.8%. The growth in the historic period can be attributed to industrial applications in food processing, enzyme replacement therapy, increasing demand in detergent industry, widespread use in pharmaceutical manufacturing, growing awareness of enzyme benefits, application in leather and textile industries, biofuel production.

The proteases market size is expected to see strong growth in the next few years. It will grow to $4.94 billion in 2029 at a compound annual growth rate (CAGR) of 8%. The growth in the forecast period can be attributed to rising demand for sustainable industrial practices, development of therapeutic enzymes, emergence of personalized medicine, application in cell culture processes, demand for enzymes in waste management, advancements in protease inhibitor research, use in novel therapeutic approaches. Major trends in the forecast period include technological integration, advancements in enzyme engineering, biological solutions in agriculture, specialty enzymes, enzyme replacement therapies, emerging markets, collaborations for research and development.

The increasing number of health-conscious consumers is anticipated to drive the growth of the proteases market in the future. Health-conscious consumers (HCCs) are individuals who lead a 'wellness-oriented' lifestyle and are concerned about their nutrition and the environment. These consumers are interested in healthier products that contain proteases, which support digestive health and promote weight management. For example, in July 2022, a report from Food Insight, a US-based non-profit organization, indicated that 52% of participants in the 2022 Food and Health Survey followed a specific diet or eating pattern, an increase from 39% in 2021. The most popular choices included clean eating (16%), mindful eating (14%), and calorie counting (13%). Therefore, the rising number of health-conscious consumers is expected to boost the demand for proteases.

An upsurge in the animal feed industry is poised to drive the proteases market's expansion. Proteases, pivotal as enzymatic supplements in animal feed formulations, significantly enhance protein digestion, contributing to optimal nutrient absorption in livestock. This advancement leads to improved feed efficiency and healthier animal growth. Notably, statistics from January 2023, indicating increased feed production in various regions including Latin America, North America, and Oceania, highlight the sector's growth. The remarkable rise, particularly in pet feed production globally, underscores the pivotal role of the animal feed industry in propelling the proteases market.

Product innovation is a significant trend gaining traction in the protease market. Major players in this sector are concentrating on developing new products to secure a competitive edge. For example, in January 2023, Selecta Biosciences, a US-based biotechnology firm, and Astellas Pharma, a Japan-based pharmaceutical company, announced a licensing and development agreement for Xork, an IgG protease enzyme. Through this agreement, Astellas acquired the exclusive global rights to develop, manufacture, and commercialize Xork, which has the potential to improve gene therapy delivery by targeting and cleaving IgG antibodies that might otherwise obstruct treatment.

Leading companies are forming collaborations and partnerships to enhance their market presence. A strategic business partnership typically involves a structured relationship between two or more companies, established through one or more agreements or contracts. For instance, in January 2023, Selecta Biosciences entered into a partnership with Astellas. This collaboration aims to license and develop an agreement for IdeXork (Xork) and to advance Astellas’s extensive gene therapy portfolio through the Selecta Biosciences clinic. Astellas Pharma Inc. is a pharmaceutical company based in Japan.

In May 2022, Vertex Pharmaceuticals, a US-based biopharmaceutical company, acquired a portfolio of protease medicines from Catalyst Biosciences Inc. for $60 million. This acquisition enhances Vertex's product offerings in protease medicines and paves the way for future growth. Catalyst Biosciences Inc. is also a US-based biotechnology firm.

Major companies operating in the proteases market are Advanced Enzymes Technologies Limited, E.l. Du Pont de Nemours & Company, Amano Enzymes Inc., Biocatalysts Limited, Koninklijke DSM NV, Dyadic International Incorporated, Specialty Enzymes & Biotechnologies Company, Associated British Foods Plc., BASF SE, Rossari Biotech Limited, Nagase & Company Limited, Jiangsu Boli Bioproducts Company Limited, Creative Enzymes Inc., Kemin Industries Inc., AB Enzymes GmbH, Lallemand Inc., Novozymes A/S, Chr. Hansen Holdings A/S, International Flavors & Fragrances Inc., Enzyme Development Corporation, Enzyme Solutions Inc., Enzyme Supplies Limited, Genencor International Inc., Kerry Group PLC, Lumis Biotech Pvt. Ltd., Megazyme International Ireland Ltd., Roche Diagnostics GmbH, Sandoz International GmbH, Sunson Industry Group Co. Ltd., The Soufflet Group, Thermo Fisher Scientific Inc., VTR Bio-Tech Co. Ltd.

North America was the largest region in the proteases market share in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the proteases market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the proteases market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Proteases encompass a diverse array of enzymes crucial for breaking down proteins. These enzymes play pivotal roles in facilitating digestion and alleviating protein-induced swelling and discomfort, aiding both bodily and skin-related processes.

The primary origins of proteases stem from animals, plants, and microbes. Animal-based proteases derive from animals and include pancreatic trypsin, chymotrypsin, pepsin, and renin. These enzymes are accessible in liquid and powder formats, finding applications across industries like food and beverage, healthcare, animal feed, among others.

The proteases market research report is one of a series of new reports that provides proteases market statistics, including proteases industry global market size, regional shares, competitors with a proteases market share, detailed proteases market segments, market trends and opportunities, and any further data you may need to thrive in the proteases industry. This proteases market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The proteases market consists of sales of glutamic, metalloproteases, cysteine, serine, threonine, and aspartic proteases. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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