High-Performance Liquid Chromatography Market Report 2026

The high-performance liquid chromatography market size has grown rapidly in recent years. It will grow from $6.73 billion in 2025 to $7.5 billion in 2026 at a compound annual growth rate (CAGR) of 11.4%. The growth in the historic period can be attributed to expansion of pharmaceutical research activities, growth in clinical diagnostics testing, increasing regulatory emphasis on drug safety, rising adoption of chromatography in food testing, availability of advanced analytical instruments.

The high-performance liquid chromatography market size is expected to see rapid growth in the next few years. It will grow to $11.62 billion in 2030 at a compound annual growth rate (CAGR) of 11.6%. The growth in the forecast period can be attributed to increasing investments in precision medicine research, rising demand for high-throughput analytical platforms, expansion of biopharmaceutical pipelines, growing use of digital chromatography data systems, increasing focus on real-time analytical monitoring. Major trends in the forecast period include increasing adoption of uhplc systems, rising demand for high-sensitivity analytical techniques, growing integration of automated sample handling, expansion of hplc use in drug development, enhanced focus on data accuracy and compliance.

The increasing number of ongoing clinical trials is expected to drive the growth of the high-performance liquid chromatography (HPLC) market in the coming years. Clinical trials are research studies involving human participants to assess the safety and effectiveness of new medical treatments, interventions, or diagnostic methods. HPLC plays a critical role in these trials by providing precise analysis of pharmaceutical compounds and biomarkers, ensuring drug safety and efficacy. It supports quality control, pharmacokinetic studies, and biomarker quantification to facilitate drug development and patient safety. For example, in December 2024, according to the Association of the British Pharmaceutical Industry (ABPI), a UK-based organization, the number of pharmaceutical industry trials launched in the UK increased for the second consecutive year, rising from 411 in 2022 to 426 in 2023. Therefore, the growing number of clinical trials is propelling the growth of the HPLC market.

Key companies in the market are developing advanced high-performance liquid chromatography (HPLC) technologies, such as integrated HPLC, for various research applications. For example, in April 2024, Waters Corporation, a U.S.-based life sciences firm, introduced the Alliance iS Bio. This system is specifically designed for biopharmaceutical applications, ensuring precise and reliable separation of complex biological molecules. It features smart technology that aids quality control analysts, thereby reducing operational errors and enhancing system performance. The system addresses up to 40% of common errors, which minimizes the time spent investigating failed runs and out-of-spec results. By improving workflow efficiency, it allows for faster and more accurate results in biopharma quality control processes.

In July 2024, Catalyze Partners, a U.S.-based firm focused on transforming innovative technologies, acquired Axcend, LLC, for an undisclosed sum. This acquisition enhances Catalyze Partners' capacity to address the growing demand for advanced analytical solutions in sectors such as pharmaceuticals, environmental monitoring, and chemical manufacturing. Axcend, LLC, is a U.S.-based company specializing in high-performance liquid chromatography systems.

Major companies operating in the high-performance liquid chromatography market are Waters Corporation, Agilent Technologies Inc., Shimadzu Corporation, Thermo Fisher Scientific Inc., PerkinElmer Inc., Bio-Rad Laboratories Inc., Merck Millipore, Hitachi Ltd., Phenomenex Inc., JASCO Corporation, Gilson Inc., Knauer GmbH, SIELC Technologies, Tosoh Bioscience LLC, YMC Co. Ltd., GL Sciences Inc., Sepax Technologies Inc., Restek Corporation, Hamilton Company, ACE HPLC Columns, Advanced Chromatography Technologies Ltd., Analytical Sales and Services Inc., Chromatography Research Supplies Inc., Daicel Corporation, Eksigent Technologies LLC, Hichrom Limited.

North America was the largest region in the high-performance liquid chromatography market analysis in 2025. Asia-Pacific is expected to be the fastest-growing region in the global high performance liquid chromatography market during the forecast period. The regions covered in the high-performance liquid chromatography market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the high-performance liquid chromatography market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The high-performance liquid chromatography market includes revenues earned by entities by providing reverse phase columns, normal phase columns, ion exchange columns, and size exclusion columns. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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