A comprehensive overview of synthetic strategies for nonaromatic nitrogen heterocycles
Nitrogen heterocycles are extremely widely distributed in nature, as well as in synthetic substances found in pharmaceuticals, agrochemicals, and materials chemistry. With new structures and medicines that include these structures emerging yearly, and a vast new journal literature to describe them, anyone who wants to be effective in R&D needs to easily access a synthesis of the latest research.
This state-of-the-art survey explores recent developments in the most widely used reactions, as well as completely new ones.
- Highlights the major modern synthetic methods known to obtain nonaromatic nitrogen heterocycles, and their practical applications
- Topics include enantioselective synthesis and catalysis, photocatalysis, biocatalysis, microwave-assisted synthesis, reactions of oximes and nitrones, and ionic liquids
- Discusses how to synthesize rings of specific sizes
- Covers sustainable synthetic approaches for obtaining salts
Whether you are using nonaromatic nitrogen compounds as an academic researcher, a synthetic chemist in industry, or an advanced student, this book is an essential, up-to-date resource to support your work.
Table of Contents
List of Contributors
Preface
List of Common Abbreviations
Chapter 1. Introduction
Chapter 2. Recent Advances in the Synthesis of Aziridines
Chapter 3. Synthesis of Four-Membered Aza-Heterocycles Through Catalytic [2+2] Cycloaddition Reactions Assisted by Metal Complexes
Chapter 4. Therapeutic Potentials of β-Lactam: A Scaffold for New Drug Development
Chapter 5. Progress in the Synthesis Of Chiral Nitrogen Heterocycles Mainly by Asymmetric [3+2] Cycloadditions
Chapter 6. Synthesis of Five-Membered N-Heterocycles by Enantioselective, Metal-Catalyzed, Intramolecular, Hydroamination of Alkenes
Chapter 7. Recent Advances in the Synthesis of Isoxazolidines
Chapter 8. Recent Advances in the Stereoselective Synthesis of Pyrrolizidin-3-ones
Chapter 9. Synthesis of Spirooxindoles by Multicomponent Reactions
Chapter 10. Modern Catalytic, Enantioselective Approaches to Piperidines
Chapter 11. Organocatalytic Enantioselective Dearomatization Reactions for the Synthesis of Nitrogen Heterocycles
Chapter 12. Synthesis of Dihydroquinolines in the XXI Century
Chapter 13. Asymmetric Aza-Diels-Alder Reaction-Application in the Synthesis of Natural Products
Chapter 14. Synthesis of Saturated Nitrogen-Containing Heterocycles Through [5+2] Cycloadditions
Chapter 15. Modern Methods for the Synthesis of 1,4-Oxazepanes and Their Oxo-Derivatives
Chapter 16. Non-Aromatic Nitrogen Heterocycles Derived from Metal-Involving Reactions of Oximes
Chapter 17. Metal-Catalyzed and Metal-Mediated Reactions of Nitrones Leading to Non-Aromatic Nitrogen Heterocyclic Systems
Chapter 18. Recent Developments in the Chemical Synthesis of Amaryllidaceae Alkaloids
Chapter 19. Enantioselective Synthesis of Nitrogen Heterocycles by Radical Reactions
Chapter 20. Recent Applications of Microwave-assisted Cyclizations Promoted by Polyphosphoric Acid Esters to the Synthesis of Nitrogen Heterocycles
Chapter 21. Biocatalysis Towards the Synthesis of Chiral Amines
Chapter 22. Photocatalytic Synthesis of Nitrogen-Containing Heterocycles
Chapter 23. Sustainable Synthetic Approaches for Nitrogen-Containing Heterocyclic Salts
Chapter 24. Noncovalent Interactions in N-Heterocyclic Chemistry: Synthesis, Catalysis and Design of Materials
