Recent Advances in the Neurological and Neurodevelopmental Impact of HIV brings together world-leading experts in the field of HIV, to provide new and critical insights into HIV treatment and management for children and adolescents. Those infected with HIV are living longer thanks to antiretroviral drugs, and HIV-related neurological and neurodevelopmental disorders therefore require urgent attention, particularly complications which arise from long-term medication use. The authors summarise key findings in these important areas, as well as gaps in research and implications for paediatric HIV work. Readers will discover ways of optimising the neurological health of children and adolescents living with HIV through better care provision and earlier intervention.
- Outlines the important clinical neurological issues facing children and young adults with HIV infection
- Presents up-to-date diagnostic and treatment approaches
- Provides practical clinical strategies to improve the care of children and adolescents with HIV
An essential resource for all clinicians involved in the care of children and adolescents with HIV and their families, including doctors, paediatricians, psychologists, and other health practitioners and researchers.
Table of Contents
Foreword
Preface
Acknowledgements
1. Epidemiology of HIV
Charles R Newton
2. Pathogenesis of HIV Involvement in the Central Nervous System
Charles R Newton
3. Neurological Manifestations of HIV Infection
Charles K Hammond and Jo M Wilmshurst
4. Neuroimaging in Children with HIV
Nicky Wieselthaler, Jacqueline Hoare, and Tracy Kilborn
5. HIV Encephalopathy
Kirsten A Donald, Nelleke G Langerak, Aleya Remtulla, and Theresa N Mann
6. Seizures and Epilepsy in Children Living with HIV
Pauline Samia, Subira Anzaya, and Jo M Wilmshurst
7. Neuroinfections in Children Infected with HIV
Brian Eley, Babatunde Ogunbosi, Ebrahim Banderker, and Charles K Hammond
8. Cerebrovascular Disease
Charles K Hammond and Alvin Ndondo
9. Tumours of the Central Nervous System in Children with HIV
Rajeshree Govender, Alan Davidson, and Beverley G Neethling
10. HIV-associated Immune Reconstitution Inflammatory Syndrome of the Central Nervous System
Rajeshree Govender and James Nuttall
11. The Effect of HIV Infection on Neurodevelopment, from Birth to 3 Years
Louisa R Mudawarima, Alliya Mohamed, and Kirsten A Donald
12. Neurodevelopmental and Mental Health Outcomes of HIV in School-age Children
Adam Mabrouk, Derrick Ssewanyana, and Amina Abubakar
13. Neurobehavioural Manifestations of HIV in Adolescence
Derrick Ssewanyana, Moses K Nyongesa, and Amina Abubakar
14. Long-term Outcomes in Adults Living with HIV
Patrick N Mwangala, Derrick Ssewanyana, Moses K Nyongesa, Felix Hosea, and Amina Abubakar
15. Neurodevelopment of Children who are HIV-exposed and Uninfected
Catherine J Wedderburn, Shunmay Yeung, and Kirsten A Donald
16. Antiretroviral Therapy and the Nervous System in Perinatally Infected Children
Eric Decloedt and Karen Cohen
17. Interventions to Enhance Developmental Outcomes of HIV-affected Children and Adolescents
Amina Abubakar, Moses K Nyongesa, Stanley W Wanjala, Micaela Rice, Sevil Ozdemir, Patrick N Mwangala, Judith K Bass, and Michael J Boivin
18. Conclusions and Future Directions
Jo M Wilmshurst and Amina Abubakar
