Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.
Table of Contents
Part-I: Mechanism of cell death in neurodegeneration1. Pathways in AD
2. Shared signalling pathways in Alzheimer’s and metabolic disease
3. Abeta pathology in AD and its potential to seed and propagate
4. Single-cell approaches to identify shared and distinct signatures across neurodegenerative diseases
5. Modelling of neurodegenerative disease using brain organoids
6. The structural basis of protein assembly into amyloid filaments in neurodegenerative disease-Benjamin
7. Blood brain barrier in neurodegenerative disorders
8. Protein misfolding in neurodegeneration
9. Neuroinflammation and neurodegeneration
10. Gut-Brain Axis in neurodegeneration
11. Modelling Neural Circuits in Parkinson’s Disease
12. Neuropathology of Parkinsonism in Alzheimer’s Disease
13. Huntington Disease updates
14. Neuroinflammation in neurodegeneration
Part-II: Gene and gene products in neurodegeneration
15. Big data and neurodegeneration disorders
16. Genomics and PD
17. RNA Binding Proteins and the Genesis of Neurodegenerative Diseases-Ahmed Moustafa, Egypt
18. Molecular Genetics of Huntington’s Disease
19. neuronopathic LSDs: opportunities and challenges
20. Nutrigenomics and PD
21. Genes and MS: updates
22. Genetic mapping and big data in ALS
Part-III: Present and future diagnostic approaches of neurodegenerative disorders
23. Biomarkers in AD
24. Biomarkers of PD
25. HMGB complex in PD diagnosis
26. Psychological assessment of PD patients
Part-IV: Present and future therapeutics of neurodegenerative disorders
27. Pharmacotherapy of neurodegenerative disorders: challenges and hopes
28. Advanced Drug Delivery Nanosystems: Perspectives and Regulatory Issues
29. Towards the Development of a Device to Improve the Gait of Patients Suffering from Parkinson’s Disease
30. Developing Antisense Therapies for Neurodegenerative Diseases
31. Advances in Gene Therapies for the CNS
32. Nutrition and PD
33. Stem cell therapy in NDG disorders
