Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Table of Contents
Section I. Overview 1. Epigenetics of Personalized Medicine Section II. Epigenetic variations Among Individuals 2. Interindividual Variability of DNA Methylation 3. Differences in Histone Modifications Between Individuals 4. Individual Noncoding RNA Variations 5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation 6. Limitations of Personalized Epigenetic Variation Comparisons Section III. Technologies for Personalized Epigenetics 7. Personalized Epigenetics Technologies 8. Computational Methods in Epigenetics Section IV. Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine 9. Epigenetic Biomarkers in Personalized Medicine 10. Epigenetic ‘Fingerprint’ 11. Epigenetics of Personalized Toxicology Section V. Environmental Personalized Epigenetics 12. Environmental Contaminants and Their Relationship to the Epigenome 13. Nutriepigenomics: Personalized Nutrition Meets Epigenetics Section VI. Pharmacology and Drug Development of Personalized Epigenetics 14. Personalized Pharmacoepigenomics 15. Epigenetics of Personalized Nanomedicine 16. Personalized Medicine and Epigenetic Drug Development Section VII. Personalized Epigenetics of Disorders and Disease Management 17. Understanding Interindividual Epigenetic Variations in Obesity and Its Management 18. Personalized Epigenetic Management of Diabetes 19. Epigenetics and Personalized Pain Management 20. Epigenetic Modification of miRNAs in Cancer 21. Epigenetics and Chemoresistance: A Personalized Approach to Cancer Therapy 22. Personalized Epigenetics and Neurological Disorders 23. Managing Autoimmune Disorders through Personalized Epigenetic Approaches 24. Cardiovascular Diseases and Personalized Epigenetics Section VIII. Challenges and Future Directions 25. Future Challenges and Prospects for Personalized Epigenetics
Authors
Trygve Tollefsbol Professor of BiologySenior Scientist, Comprehensive Cancer Center
Senior Scientist, Comprehensive Center for Healthy Aging
Senior Scientist, Comprehensive Diabetes Center
Senior Scientist, Nutrition Obesity Research Center
Director, Cell Senescence Culture Facility
University of Alabama at Birmingham, AL, USA. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
