The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.
Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation.
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Table of Contents
PrefaceBahareh Dabirmanesh and Vladimir N. Uversky
1. Protein Aggregation: An Overview
Vladimir N. Uversky
2. Pathways of Amyloid Fibril Formation and Aggregation
Bahareh Dabirmanesh and Fatemeh Aziziyan
3. Factors Influencing Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
4. Morphological Features and Types of Aggregated Structures
Vladimir N. Uversky
5. Each big journey starts with a first step: Importance of Oligomerization
Vladimir N. Uversky
6. Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation
Vladimir N. Uversky
7. Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils
Bahareh Dabirmanesh and Farnoosh Farzam
8. Prediction of Protein Aggregation
Khosro Khajeh
9. Amyloid Fibril Cytotoxicity and Associated Disorders
Khosro Khajeh
10. Inhibitors of Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
11. Therapeutic Approaches in Proteinopathies
Vladimir N. Uversky
12. Functional Amyloids
Bahareh Dabirmanesh
13. Biotechnological Applications of Amyloid Fibrils
Bahareh Dabirmanesh
14. The Hidden World of Protein Aggregation
Bahareh Dabirmanesh and Vladimir N. Uversky
