Nanomedicine is the study and application of nanomaterials-based medical techniques. In recent years it has very rapidly become indispensable in a huge range of medical contexts, from analysis of extreme life events to diagnosis and treatment of life-threatening intractable diseases, such as cancers and cardiovascular diseases. It has already transformed both research and clinical outcomes in many areas of medicine and promises to continue as the cutting-edge research and clinical area for the next generation of medical specialists.
Nanomedicine: Fundamentals, Synthesis, and Applications constitutes a comprehensive guide to this subfield and its recent advances. Beginning with a brief history of the field and introduction to its core principles, it thoroughly treats recent developments in this vital and ever-growing field. Its multidisciplinary approach equips the reader with a systematic overview of these life-saving developments in medicine.
Nanomedicine readers will also find: - Edited by a leading researcher with decades of experience in both North America and China- Detailed treatment of subjects including nanocarriers, nanomaterial bioprobes, multi-function nanodrugs, nanomedicine-mediated immunotherapy and/or physical ablation, and more- A comprehensive volume treats every facet of the subject
Nanomedicine is a vital resource for biochemists, biomedical engineers, pharmaceutical chemists, physicists, and professionals in the biotechnological industries, as well as for clinicians looking to familiarize themselves with nanomedical techniques and instrumentation.
Table of Contents
Preface xv
1 State of the Art in Nanomedicine 1
Yujun Song and Wei Hou
1.1 Intractable Diseases and Development of the Related Novel Therapy and Medicines 1
1.2 Key Features of Nanomedicines 4
1.3 Nanotechnology Translational Nanomedicine: Emergence and Progress 6
1.4 Interdisciplinary Features of Nanomedicines: Multi-mode and Multi-function Features Promoting Nanomedicine-mediated Immunotherapy and/or Physical Field Ablation Therapy for Subversive Therapy 12
1.5 Future Development of Nanomedicines by Coupling Advanced Biomedicines (Including Biochemistry and Biophysics), Modern Physicochemical Technologies, and Artificial Intelligence Technology 27
2 Fundamentals in Nanomedicine 49
Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao
2.1 Design Theory of Nanomedicines 49
2.2 Progress in the Controlled Synthesis of Nanomaterials 55
2.3 Progress in the Surface Modification and Functionalization of Nanomaterials for Nanomedicines 60
3 Nanomedicine for Antitumors 73
Qiong Wu, Xinzhu Yang, Ruixue Zhu, and Yujun Song
3.1 Introduction 73
3.2 Liposomal Nanoparticles 75
3.3 Polymeric Nanoparticles 78
3.4 Inorganic Nanoparticles 82
3.5 Mixture (Hybrid) Nanoparticles 90
3.6 Cell Membrane Coating Nanotechnology 93
3.7 Challenges and Current Limitations 94
3.8 Conclusions 96
4 Nanomedicine for the Treatment of Nervous System Diseases 113
Xiaojian Cui and Yujun Song
4.1 Concepts and Types of Nanomedicines for Nervous System Diseases 113
4.2 Therapeutical Methods for Nervous System Diseases and Features of Current Nanomedicines 114
4.3 Synthesis Methods and Typical Examples (Including Clinical Trial) of Polymer-based Nanomedicines for Nervous System Diseases 116
4.4 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 117
4.5 Metallic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 122
4.6 Multifunctional Nanomedicines for Nervous System Diseases 125
5 Nanomaterial Translational Nanomedicine for Anti-HIV and Anti-bacterial 131
Hao Luo and Yujun Song
5.1 Concepts, Anti-HIV Theory, and Types and Features of Current Nanomedicines 132
5.2 Polymer-based Nanomedicines: Synthesis Methods and Typical Application 142
5.3 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application 146
5.4 Metallic-based Nanomedicines: Synthesis Methods and Typical Application 148
5.5 Multi-functional (Target) Nanomedicines 150
5.6 Future Development 152
6 Nanomedicine for Next-generation Dermal Management 157
Haibin Wu, Qian Chen, and Shen Hu
6.1 Introduction 157
6.2 Nano-biomaterials-based Therapeutics forWound Healing 159
6.3 Nano-biomaterials for Imaging and Monitoring of Cutaneous Wounds 176
6.4 Conclusion and Future Outlook 181
7 Nanomedicine for Targeting Delivery of Gene and Other DNA/RNA Therapies Based Viruses Engineering 197
Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao
7.1 Targeting Delivery of Gene Therapies to the Tumors 198
7.2 Targeting Delivery of Gene-based Nanovaccines to the Spleen 199
7.3 Targeting Delivery of Gene-based Nanovaccines to the LNs 200
7.4 Targeting Delivery of Gene-based Nanomedicines to the Liver 200
7.5 Targeting Delivery of Gene-based Nanomedicines to the Lung 200
7.6 Targeting Delivery of Gene-based Nanomedicines to the Brain 202
8 Nanomedicine for Bio-imaging and Disease Diagnosis 207
Ziqi Wang and Yujun Song
8.1 Concepts, Types, and Features of Current Nanoprobes 207
8.2 Synthesis Methods 214
8.3 Typical Application Examples in the Disease Diagnosis and Study of Biological Events 219
8.4 Future Development 224
9 Magnetic Nanoparticles and Their Applications 227
Xiuyu Wang and Yuting Tang
9.1 Introduction 227
9.2 Classification of Magnetic Nanoparticles 228
9.3 Biomedical Applications 236
9.4 Conclusion and Outlook 242
10 Nanomedicine-mediated Immunotherapy 245
Wei Hou and Yujun Song
10.1 Immune System and Immune Response 245
10.2 Mechanism of Tumor Immunotherapy 247
10.3 Mechanism of Nanomedicine-enhancing Immunotherapy 248
10.4 Immunological Applications of Nanomedicines 252
10.5 Summary and Outlook 263
11 Nanomedicine-mediated Ultrasound Therapy 269
Qingwei Liao, Yaoyao Liao, and Wei Si
11.1 Concept, Therapy Theory, and Devices 269
11.2 Nanomedicine Synthesis with Ultrasound Field Response 274
11.3 Application Examples 275
12 Nanomedicine-mediated Photodynamic and/or Photothermal Therapy 279
Shangqing Jing and Yujun Song
12.1 Photodynamic and Photothermal Mechanism for Anti-cancer 281
12.2 Nanomaterial-based PSs (Nano-PSs) for PDT 283
12.3 Photodynamic and Photothermal Synergistic Therapy 291
12.4 Opportunities and Challenges 292
12.5 Summary 293
13 Nanomedicine-mediated Pulsed Electric Field Ablation Therapy 299
Xinzhu Yang, Qiong Wu, Ruixue Zhu, and Yujun Song
13.1 Introduction 299
13.2 Concept, Therapy Theory, and Devices 302
13.3 Synthesis of Nanomedicine with Electric Field Response 312
13.4 Application Examples 322
13.5 Conclusion 323
14 Nanomedicine-mediated Magneto-dynamic and/or Magneto-thermal Therapy 329
Yangfei Wang and Yujun Song
14.1 Concepts, Treatment Theories, and Methods 329
14.2 Treatment Theories and Methods 330
14.3 Magnetic Field-responsive Nanomedicine Synthesis 333
14.4 Applications 337
15 Nanomedicine-mediated Radiotherapy for Cancer Treatment 341
Ruixue Zhu and Yujun Song
15.1 Concept, Therapy Theory, and Devices 341
15.2 Nanomaterials as Radiosensitizers for Radiation Therapy 347
15.3 Nanomaterials Delivering Radioisotope for Internal Radioisotope Therapy 358
15.4 Nanomedicine Synthesis with Radio/Nuclear Radiation Response 362
15.5 Conclusion and Prospects 364
16 Nanomedicine Conjugating with AI Technology and Genomics for Precise and Personalized Therapy 371
Lin Liu, Siyu Chen, and Sen Zhang
16.1 Concept 371
16.2 Genomics of Nanomedicine 374
16.3 Artificial Intelligence Technology in Nanomedicine Development 377
16.4 Artificial Intelligence Facilitates Precise and Personalized Nanomedicine Based on Genomics 379
17 Microfluidic Conjugating AI Platform for High-throughput Nanomedicine Screening 385
Xing Huang, Wenya Liao, Zhongbin Xu, and Yujun Song
17.1 Introduction 385
17.2 Microfluidic Technologies for Medicine Development 386
17.3 Microfluidic Preparation of Nanomedicines 391
17.4 Microfluidic High-throughput Drug Screening 396
17.5 AI-assisted Microfluidic Development of Nanomedicine 400
17.6 Conclusions and Perspectives 402
References 404
Index 413
