Hepatology. An Evidence-Based Clinical Compendium

Table of Contents

1. Anatomy and Histopathology of the Liver
2. The Liver and Immunology
3. Bilirubin metabolism and its disorders
4. Non-invasive diagnosis of Metabolic dysfunction associated steatotic liver disease (MASLD)
5. Hematological Conditions and the Liver
6. Acute Liver Failure (ALF)
7. Acute-on-Chronic Liver Failure
8. Hepatic Fibrogenesis
9. Cirrhosis, portal hypertension and pathophysiology
10. Ascites and Hepatorenal Syndrome
11. Management of Esophageal and Gastric Varices
12. Hepatic Encephalopathy
13. Jaundice/Cholestasis
14. Gallstones and Gall bladder Disorders
15. Benign Biliary Stricture: Causes and management
16. Hepatic and Biliary Cystic Lesions: Diagnosis, Management and Therapeutic Options
17. Congenital Biliary Diseases
18. Primary Biliary Cholangitis
19. Primary Sclerosing Cholangitis
20. Enterically Transmitted Viral hepatitis- Hepatitis A through E
21. Hepatitis B
22. Hepatitis C
23. The Worldwide Medical Impact of Hepatitis D Virus Infection: Focus to Central Asia
24. Hepatitis through non A-E viruses
25. HIV related Liver Diseases
26. Autoimmune hepatitis
27. Diagnosing drug induced liver injury
28. Alcohol-Associated Liver Disease
29. Iron Overload and Liver
30. Wilson Disease
31. Metabolic-dysfunction Associated Steatotic liver disease (MASLD)
32. Sarcopenia, Frailty and its Implications in Cirrhosis
33. Liver in neonate, infancy and childhood
34. Pregnancy Related Liver Disease
35. Viral Hepatitis and Pregnancy
36. Liver in Systemic Diseases, Part 1
37. Liver in Systemic Diseases, Part 2
38. Bacterial, Fungal and Parasitic infections and the Liver
39. Parasitic Diseases of the Liver and Biliary Tract
40. Benign Liver Tumors
41. Malignant Liver Tumors
42. Liver Targeted Therapies for Benign and Malignant Tumors of the Liver
43. Liver Transplantation
44. Liver Transplantation in Combination with Other Organs
45. Surgical aspects of Liver Transplantation
46. COVID-19 and the Liver
47. Inherited and Metabolic disorders of the liver
48. Liver and Radiology
49. Gall Bladder Cancer

Authors

Sanjaya K. Satapathy Interim Chief, Division of Hepatology; Medical Director, Liver Transplantation; and Program Director, Transplant Hepatology Fellowship. Dr. Sanjaya Satapathy is a Professor of Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra University. He serves as the Interim Chief of Hepatology and Medical Director of Liver Transplantation at the Northwell Center for Liver Diseases & Transplantation, Northshore University Hospital. Dr. Satapathy is also the Program Director of Transplant Hepatology Fellowship at the Zucker School of Medicine/Northwell Health. His research focuses on NAFLD, Hepatitis C, post-transplant outcomes, NASH, sarcopenia, and hepatitis C. With over 160 peer-reviewed publications in high-impact journals, he is a recognized expert in the field. Dr. Satapathy is board certified in Internal Medicine, Gastroenterology, and Transplant Hepatology. He has received numerous accolades, including grants from NIH, and is a Fellow of various prestigious medical societies. Mamun Al-Mahtab Chairman, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University.

Mamun Al Mahtab is a notable hepatologist, medical scientist, author, and columnist from Bangladesh. With an impressive portfolio of 290 publications in national and international peer-reviewed journals, Dr. Mahtab currently serves as the Head of the Division of Interventional Hepatology at Bangabandhu Sheikh Mujib Medical University (BSMMU). Dr. Mahtab plays a crucial role in medical research and development. He leads the clinical study of the Bangladesh-developed SARS-CoV-2 mRNA candidate, GBPD060. Additionally, he serves as the lead researcher for NASVAC's Phase I/II and III clinical studies. Notably, his discovery of NASVAC earned him the prestigious 'Premio Nacional' award from the Cuban Academy of Sciences in 2019. Apart from his research endeavors, Dr. Mahtab actively organizes awareness programs on liver diseases throughout Bangladesh. He is also credited with inventing the NASVAC drug, which aims to provide an affordable and effective solution for Hepatitis B to the masses in Bangladesh.

Shivaram Prasad Singh Professor, Department of Gastroenterology, S.C.B. Medical College.

Dr. Shivaram Prasad Singh is a highly accomplished medical professional. He graduated from Utkal University with degrees in MBBS and MD in Internal Medicine. He obtained his DM from C.M.C., Vellore at Madras University, India. Dr. Singh is a Fellow of the Society for Gastrointestinal Endoscopy of India, the American College of Gastroenterology, and the American Gastroenterological Association.

His remarkable contributions include initiating World Hepatitis B Eradication Day in India, endorsed by WHO, and serving on the World Hepatitis Alliance Public Health Panel. Dr. Singh held leadership positions in renowned organizations such as INASL and ISG. He has received prestigious awards, including the ISG S.R. Naik Memorial Award for Research Publications and the Indian Society of Gastroenterology Zydus Oration.

With over 160 publications and numerous national guideline papers, Dr. Singh is an acclaimed authority in gastrointestinal and liver diseases. He currently serves as the President-Elect of INASL.

Sheikh Mohammad Fazle Akbar Senior Researcher, Department of Gastroenterology and Metabology.

Dr. Akbar is an esteemed researcher in epidemiology, clinical studies, and immunology, focusing on chronic diseases like cancers. His molecular analysis has provided valuable insights into HBV, HCV, and HEV in Bangladesh, Nepal, Indonesia, and Japan. He developed a groundbreaking immune therapeutic drug for chronic hepatitis B and cancers, completing successful phase I/II and II clinical trials, with approvals in select countries. As a core member of the US-Japan Cooperative Medical Science Program (USJ CMSP), he contributes to global health research. Dr. Akbar has authored 150+ articles, compiled books, and holds editorial roles.

Aftab Ala Aftab Ala Institute of Liver Studies Kings College Hospital London, UK United Kingdom University of Surrey Guildford, UK.

Professor Aftab Ala, MBBS, MD, PhD, FRCP, is

Professor of Hepatology and Consultant Hepatologist

at the Institute of Liver Studies at King's College

Hospital in London, UK, and the University of

Surrey, Guildford, UK, and Chair of the Rare Liver

Disease Special Interest Group at the British Association

for the Study of the Liver (BASL).

He obtained his medical qualification from

Charing Cross and Westminster (Imperial College

Medical School) in London in 1992. Professor

Ala pursued specialized training in Gastroenterology

and Hepatology at King's and Royal Free Hospitals

in London and Advanced Hepatology

Fellowship at Mount Sinai Hospital in New York,

USA, from 2003 to 2004 where he focused on rare liver and inherited metabolic liver

diseases and liver transplantation. He subsequently won an International Sheila Sherlock

Royal College of Physicians Fellowship at the Center of Excellence for Wilson

Disease, Yale University, USA.

Professor Ala earned a PhD from University College, London, in 2005 and

received a Wellcome Trust Research Training fellowship successfully focusing on

immune and inflammatory mechanisms that connect liver and gut diseases.

Professor Ala has made significant contributions to the field of medicine,

research, and education. His ongoing research and clinical trials programs (phases

1-3) in complex liver disease and health inequality are supported by international

industry partners, the UK National Institute for Health and Care Research (NIHR)

and the UKRI/MRC Thomas D Schiano Medical Director, Intestinal Transplantation; Director of Clinical Hepatology; Medical Director, Adult Liver Transplantation at Mount Sinai Medical Center.

Dr. Thomas D. Schiano is a highly skilled medical professional with expertise in hepatology, gastroenterology, and clinical nutrition. He specializes in the management of cirrhosis, liver diseases, and pre- and post-liver transplantation care. Dr. Schiano's clinical research interests encompass various areas, including alcohol-related liver disease, nutritional aspects of liver disease, recurrence of disease post-transplantation, living donor liver transplantation, and complications of cirrhosis. He is actively involved in the care of patients undergoing intestinal transplantation and is a member of the liver thrombosis program, an international referral center for complex blood clotting disorders affecting the liver and intestines.

As a UNOS-certified Liver Transplant physician, Dr. Schiano holds board certifications in clinical nutrition, gastroenterology, and transplant hepatology. Currently, Dr. Schiano serves as a Professor of Medicine, Medical Director of Adult Liver Transplantation, and Director of Clinical Hepatology at the Recanati/Miller Transplantation Institute. He is also the Medical Director of the Intestinal Transplant program.