Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.
Table of Contents
1. Maintenance of balanced proteome homeostasis 2. Determinants of protein misfolding, aggregation in neuronal cell death 3. Classification, structure, and function of protein aggregates in proteinopathies 4. Protein aggregation and cellular and molecular mechanisms in neurodegenerative disease 5. Advances in methods to detect and study protein aggregation 6. Organelle specific protein quality control 7. Molecular chaperones and co-chaperones in proteostasis 8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal proteolytic pathways 9. Alterations in protein quality control 10. Alternate mechanisms to maintain proteome homeostasis 11. Advances in developing novel therapeutics, strategies, approaches and use of emerging techniques 12. Challenges in translating laboratory findings to drug development 13. Advancements in drug delivery technologies for protein misfolding diseases
Authors
Neha Gogia Post-Doctoral Associate, Yale University, Connecticut, USA. Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University's International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases. Sandeep Kumar Singh Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India.Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. He's a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.
Vidyadhara Devarunda Jaganath Department of Neurology and Neuroscience, Yale University School of Medicine, CT, USA. Vidyadhara Devarunda Jaganath works in the Department of Neurology and Neuroscience, Yale University School of Medicine, CT, USA.
