The Handbook of Dopamine explores the function of dopamine neurons that spans from molecular, cellular, synaptic, and circuits to behavior, and finally, dysfunction in disease. This volume maps out the anatomical organization and molecular diversity of dopamine that is increasingly better understood through large scale analyses. It compiles the latest research from many prominent figures still involved in dopamine research with content included that reflects many new developments, such as genetic analyses, manipulations, optogenetics, fluorescent probes, real-time optical imaging, multichannel recordings, behavioral analyses, and human neuron modeling.
Table of Contents
Introduction: A general perspective on dopamineSection 1: Molecular neuroanatomy of dopamine neurons: Development, diversity and connectivity
1. The dopamine system in an evolutionary perspective
2. Molecular heterogeneity of midbrain dopamine neurons
3. Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons
4. Anatomy of dopamine neuron projections: AXONAL arbours, varicosities, and synapses
5. DA neuron connectomes: Inputs and outputs
Section 2: Dopamine neuron physiology and dopamine release regulation
6. Electrical patterns of activity in dopamine midbrain neurons {i in vivo}
7. Computational modeling of midbrain dopamine neurons
8. Axonal DA release: Molecular mechanisms
9. Somatodendritic DA release
10. Regulation of dopamine transmission by striatal neuromodulators
11. DA transporters and the nanoscale organisation of the DA axon
12. Beyond DA: Co-transmission by DA neurons
Section 3: Dopamine signalling: receptors, postsynaptic integration and plasticity
13. Unveiling Activation Mechanisms and Intrinsic Divergence of the Dopamine Receptors Based on Experimentally Determined Structures
14. DA receptor drugs and their applications
15. Postsynaptic integration and plasticity in the striatum
16. DA signalling roles in the extrastriatal basal ganglia
17. Postsynaptic integration and plasticity in prefrontal cortex
Section 4: Dopamine mechanisms of learning and reinforcement
18. The dopamine reward prediction error signal
19. Diversity of encoding: Reward to aversion
20. Dopamine beyond temporal-difference reinforcement learning
21. Habits and dopamine
22. Dopamine for performance evaluation insights from songbirds
23. Striking parallels between the dopaminergic systems of flies and mammals
24. Computing with dopamine: a convergence of natural and artificial intelligence
Section 5: Dopamine function in motivated behaviour
25. Dopamine and the temporal control of behavior
26. Volition and vigour
27. Effort and activation
28. Exploration and behavioral variability
29. Role of dopamine in adaptively tuning motivational bias to the current environment
30. Sex differences in Dopamine Systems involved in Motivation and Reward
31. Dopamine and appetite
Section 6: Dopamine dysregulation: from neurology to psychiatry
32. Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson’s disease
33. Understanding human dopamine neuron biology in Parkinson's patient cells
34. Dopamine replacement for Parkinson's disease: clinical approaches and experimental underpinnings
35. Dopamine modulation of synaptic transmission in drug addiction
36. Molecular Reprogramming of D1 and D2 Dopaminoceptive Medium Spiny Neurons in Substance Use Disorder
37. Human DA systems in addiction disorders
38. Apathy and Impulsivity in Neurological and Psychiatric disorders
39. Dopamine dysfunction in psychosis
40. Dopamine systems in impulsive-compulsive behaviour
Authors
Stephanie J. Cragg Professor of Neuroscience, Oxford University, UK.Dr. Stephanie Cragg is a professor of neuroscience at Oxford University. She runs a laboratory on understanding dopamine neurotransmission.
Mark Walton Professor of Behavioral Neuroscience, Oxford University, UK. Dr. Mark Walton is currently a professor of behavioral neuroscience at Oxford University. His laboratory, the Walton Lab, researches how value is learned and influences decision making within defined brain systems.
