The global bone graft substitute (BGS) market was valued at approximately $2.83 billion in 2024 and is expected to grow at a CAGR of 4.1%, reaching approximately $3.75 billion by 2031. The market includes various types of bone graft substitutes used in orthopedic, trauma, and reconstructive surgeries.
The BGS market is segmented into:
- Allograft BGS
- Demineralized Bone Matrix (DBM) Allograft BGS
- Synthetic BGS
The market is further categorized based on indication type:
- Spine (Cervical, Thoracolumbar)
- Trauma (Non-union, Fresh Fracture)
- Large Joint Reconstruction (Hip, Knee)
- Craniomaxillofacial
- Oncology
- Foot Bone Reconstructions
Market Insights
- Unit Sales & Average Selling Prices
- Market Size & Growth Trends
- Procedure Numbers
- Market Drivers & Limiters
- Market Forecasts Until 2031
- Recent Mergers & Acquisitions
- Competitive Landscape
- Company Profiles & Product Portfolios
Market Trends
- The COVID-19 pandemic caused a decline in BGS sales due to postponed elective surgeries. However, the market recovered strongly by 2022 and resumed steady growth.
- Minimally invasive techniques are driving the adoption of synthetic and DBM-based grafts over traditional bone grafting procedures.
- Rising orthopedic procedures due to an aging population and increasing trauma-related injuries are fueling market growth.
- Technological advancements in bioengineered bone grafts are increasing graft efficiency and patient outcomes.
Market Share Insights
Top Competitors in the Global Bone Graft Substitute Market (2024):1 Medtronic
- Market leader due to a dominant share in the DBM and synthetic BGS segments.
- Grafton® - The first fiber-based DBM allograft BGS and one of the most widely used.
- MASTERGRAFT® - Synthetic BGS product line available in granules, moldable putty, flexible strip, and matrix EXT.
2 Stryker
- Second-largest competitor in the market.
- Offers multiple BGS products including Vitoss™, ALLOMATRIX®, FUSIONFLEX®, and PRO-STIM®.
- Third-largest competitor in the BGS market.
- Competes with its DBX® DBM product line and chronOS® synthetic BGS.
Global Research Scope
- Regions Covered:
- North America: United States, Canada
- Latin America: Brazil, Mexico, Chile, Colombia
- Western Europe: Germany, France, Italy, Spain, United Kingdom
- Central & Eastern Europe: Poland, Russia, Turkey
- Middle East: Saudi Arabia, UAE, Israel
- Asia Pacific: China, Japan, India, South Korea
- Africa: South Africa, Egypt, Nigeria
- Base Year: 2024
- Forecast Period: 2025-2031
- Historical Data: 2021-2023
Quantitative Coverage
- Market Size
- Market Shares
- Market Forecasts
- Market Growth Rates
- Units Sold
- Average Selling Prices
- Procedure Numbers
Qualitative Coverage
- COVID-19 Impact
- Market Growth Trends
- Market Limiters
- Competitive Analysis & SWOT for Top Competitors
- Mergers & Acquisitions
- Company Profiles
- Product Portfolios
- FDA Recalls
- Disruptive Technologies
- Disease Overviews
Data Sources
- Primary Interviews with Industry Leaders
- Government Physician Data
- Regulatory Data
- Hospital Private Data
- Import & Export Data
- Internal Database
Table of Contents
- Executive Summary
- Global Orthopedic Bone Graft Substitute Market Overview
- Competitive Analysis
- Regions Included
- Introduction
- Procedure Numbers
- Total Orthopedic Bone Grafting Procedures
- Allograft Procedures
- Demineralized Bone Matrix Procedures
- Synthetic Procedures
- Market Overview
- By Segment
- By Region
- Market Analysis and Forecast
- Total Orthopedic Bone Graft Substitute Market
- Allograft Bone Graft Substitute Market
- Demineralized Bone Matrix Allograft Bone Graft Substitute Market
- Synthetic Bone Graft Substitute Market
- Synthetic Bone Graft Substitute Market by Generation Type
- Unit Analysis
- Allograft Bone Graft Substitute Unit Analysis
- Allograft Bone Graft Substitute Units Sold by Indication
- Spine Allograft Bone Graft Substitute Units Sold
- Trauma Allograft Bone Graft Substitute Units Sold
- Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold
- Demineralized Bone Matrix Allograft Bone Graft Substitute Unit Analysis
- Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold by Indication
- Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- Synthetic Bone Graft Substitute Unit Analysis
- Synthetic Bone Graft Substitute Units Sold by Indication
- Spine Synthetic Bone Graft Substitute Units Sold
- Trauma Synthetic Bone Graft Substitute Units Sold
- Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold
- Drivers and Limiters
- Market Drivers
- Market Limiters
- Competitive Market Share Analysis
- Orthopedic Bone Graft Substitute Market, Global, 2024 & 2031
- Orthopedic Bone Graft Substitute Procedures, Global, 2024
- Orthopedic Bone Grafting Procedures by Segment, Global, 2021- 2031
- Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 - 2031
- Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 - 2031
- Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
- Orthopedic Bone Graft Substitute Regions Covered, Global
- Orthopedic Bone Grafting Procedures by Segment, Global, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Region, Global, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Country, North America, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Country, Latin America, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Country, Western Europe, 2021- 2031
- Orthopedic Bone Grafting Procedures by Country, Central & Eastern Europe, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Country, Middle East, 2021 - 2031
- Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021- 2031
- Orthopedic Bone Grafting Procedures by Country, Africa, 2021 - 2031
- Allograft Procedures by Region, Global, 2021- 2031
- Allograft Procedures by Country, North America, 2021- 2031
- Allograft Procedures by Country, Latin America, 2021- 2031
- Allograft Procedures by Country, Western Europe, 2021 - 2031
- Allograft Procedures by Country, Central & Eastern Europe, 2021 - 2031
- Allograft Procedures by Country, Middle East, 2021- 2031
- Allograft Procedures by Country, Asia-Pacific, 2021 - 2031
- Allograft Procedures by Country, Africa, 2021- 2031
- Demineralized Bone Matrix Procedures by Region, Global, 2021- 2031
- Demineralized Bone Matrix Procedures by Country, North America, 2021- 2031
- Demineralized Bone Matrix Procedures by Country, Latin America, 2021- 2031
- Demineralized Bone Matrix Procedures by Country, Western Europe, 2021 - 2031
- Demineralized Bone Matrix Procedures by Country, Central & Eastern Europe, 2021 - 2031
- Demineralized Bone Matrix Procedures by Country, Middle East, 2021 - 2031
- Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021- 2031
- Demineralized Bone Matrix Procedures by Country, Africa, 2021 - 2031
- Synthetic Procedures by Region, Global, 2021 - 2031
- Synthetic Procedures by Country, North America, 2021 - 2031
- Synthetic Procedures by Country, Latin America, 2021 - 2031
- Synthetic Procedures by Country, Western Europe, 2021- 2031
- Synthetic Procedures by Country, Central & Eastern Europe, 2021 - 2031
- Synthetic Procedures by Country, Middle East, 2021 - 2031
- Synthetic Procedures by Country, Asia-Pacific, 2021 - 2031
- Synthetic Procedures by Country, Africa, 2021 - 2031
- Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 - 2031 (US$M)
- Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 - 2031 (US$M)
- Orthopedic Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Orthopedic Bone Graft Substitute Market, Global, 2021- 2031 (US$)
- Market Value by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Allograft Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Allograft Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Allograft Bone Graft Substitute Market, Global, 2021 - 2031 (US$)
- Market Value by Region, Allograft Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 - 2031 (US$)
- Market Value by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$)
- Market Value by Region, Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$)
- Market Value by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Units Sold by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031
- Average Selling Price by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$)
- Market Value by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 - 2031 (US$M)
- Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 - 2031
- Spine Allograft Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Trauma Allograft Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold, Global, 2021- 2031
- Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 - 2031
- Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Synthetic Bone Graft Substitute Units Sold by Indication, Global, 2021 - 2031
- Spine Synthetic Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Trauma Synthetic Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold, Global, 2021 - 2031
- Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- AbbVie
- LCA Pharma
- Acumed
- LifeLink Tissue Bank
- AlloSource
- LifeNet Health
- Alphatec Spine
- Meda Pharma
- Anika Therapeutics
- Medtronic
- Arthrex
- MTF
- B. Braun Melsungen
- Novabone
- Baxter
- Nuo Therapeutics
- Berkeley Advanced Biomaterials
- Octane Medical
- Biocell
- Orthocell Ltd.
- Biocomposites
- OrthogenRx
- Biogennix
- Orthofix
- Bioiberica
- Osteogenics
- Biomatlante
- OsteoMed
- Biotissue Technologies
- Paragon 28
- Bioventus
- Plasmaconcept
- Bonalive
- PromoCell
- Celling Biosciences
- Rebone Biomaterials
- Cerapedics
- Recordati
- Cingal
- Regenexx
- Croma-Pharma
- Regenity Biosciences
- CO.DON GmbH
- RTI Surgical
- CONMED
- Sanofi
- Curasan
- Sartorius CellGenix GmbH
- DCI Donor Services
- Seikagaku
- DePuy Synthes
- Smith & Nephew
- Documedica
- Solvita
- Elutia Inc.
- Spinal Elements
- Exactech
- Stella Pharmaceuticals
- Ferring Pharmaceuticals
- Stryker
- Fidia
- Takara Bio
- Finceramica
- Tedec-Meiji
- Geistlich
- Terumo
- Globus Medical/NuVasive
- Teva Pharmaceutical
- Hanmi Pharmaceutical
- ThermoGenesis
- Healiva
- TRB Chemedica
- IBSA Pharma
- Viatris
- Integra LifeSciences
- Vericel
- Isto Biologics
- Vivex
- Kolon Tissuegene
- Xtant Medical
- Kuros
- Zimmer Biomet
