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Nucleotidases are enzymes that catalyze the hydrolysis of nucleotides into their component parts, such as nucleosides, phosphates, and bases. They are involved in the metabolism of nucleic acids and play an important role in the regulation of cellular processes. Nucleotidases are classified into two main categories: exonucleases, which cleave nucleotides from the ends of a polynucleotide chain, and endonucleases, which cleave nucleotides from within the chain.
Nucleotidases are used in a variety of applications, including the production of nucleoside analogs for pharmaceuticals, the detection of nucleic acid sequences, and the study of gene expression. They are also used in the diagnosis and treatment of genetic diseases, such as cystic fibrosis and muscular dystrophy.
The nucleotidase market is highly competitive, with a number of companies offering a range of products. Companies in the market include Sigma-Aldrich, Merck, Roche, Novozymes, and Bio-Rad. These companies offer a variety of nucleotidase products, including enzymes, substrates, and kits. They also provide services such as custom enzyme production and assay development. Show Less Read more