Results for tag: "Beta Secretase"

Beta Secretase (BACE1) is an enzyme that plays a key role in the production of amyloid-beta peptides, which are associated with Alzheimer's disease. BACE1 is a type of aspartic protease, which is a class of enzymes that cleave proteins at specific sites. BACE1 is responsible for the initial cleavage of the amyloid precursor protein (APP) into amyloid-beta peptides. Inhibiting BACE1 activity has been proposed as a potential therapeutic strategy for Alzheimer's disease. BACE1 inhibitors are being developed by a number of pharmaceutical companies, including Merck, Eli Lilly, and Biogen. These companies are researching and developing small molecule inhibitors, monoclonal antibodies, and other therapeutic agents that target BACE1. Additionally, several biotechnology companies are developing BACE1 inhibitors, such as Alector, Denali Therapeutics, and Proclara Biosciences. Show Less Read more