Heat Biologics is a biopharmaceutical company that develops novel allogeneic off-the-shelf cellular therapeutic vaccines for a range of cancers and infectious diseases in the United States. It is focused on developing its proprietary "ImPACT" (Immune Pan-Antigen Cytotoxic Therapy), a cell-based immunotherapy for use in the treatment of a wide range of cancers. Heat is currently conducting multiple clinical trials in two indications with its ImPACT therapy based products. The company was founded in 2008 and is based in Durham, North Carolina.