This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology.
Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere.
Table of Contents
Section 1 Introduction1. A history of viral infections of the central nervous system: Foundations, milestones, and patterns
2. Basics of virology
3. Neuroepidemiology and the epidemiology of viral infections of the nervous system
4. Clinical approach to the syndromes of encephalitis, myelitis and meningitis
5. Laboratory diagnosis of viral disease
6. Neuroimaging of viral infections of the central nervous system
7. Viral neuropathogenesis
8. Neuropathology of viral infections
9. Innate immune viral recognition: Relevance to CNS infections
10. Adaptive immune response to viral infections in the central nervous system
Section 2 DNA viruses
11. Herpes simplex virus
12. Varicella zoster
13. Epstein-Barr virus infections of the nervous system
14. Cytomegalovirus infections of the adult human nervous system
15. Congenital cytomegalovirus infection
16. Human herpesvirus-6 and the nervous system
17. Progressive multifocal leukoencephalopathy
Section 3 RNA viruses
18. Enterovirus/picornavirus infections
19. The equine encephalitides
20. West Nile and St. Louis encephalitis viruses
21. The Bunyaviridae
22. Human endogenous retroviruses and the nervous system
23. Central nervous system HIV-1 infection
24. Neurological disease due to HTLV-1 infection
25. Tick-borne encephalitis
26. Japanese encephalitis virus infection
27. Measles virus and the nervous system
28. Mumps and rubella
29. Rabies
30. Neurologic aspects of influenza viruses
31. Neurological complications of hepatic viruses
32. Henipavirus encephalitis
33. Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses
Section 4 Other topics concerning viral or presumed viral infections of the CNS
34. Nervous system viral infections in immunocompromised hosts
35. Acute disseminated encephalomyelitis
36. Vaccines and viral / toxin associated neurological infections
37. Encephalitis lethargica (von Economo's encephalitis)
38. Bell's palsy and vestibular neuronitis
