Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine discusses recent advances in science and technology using nanoscale units that show the novel concept of combining nanotechnology with various research disciplines within both the biomedical and medicine fields. Self-assembly of molecules, macromolecules, and polymers is a fascinating strategy for the construction of various desired nanofabrication in chemistry, biology, and medicine for advanced applications. It has a number of advantages: (1) It is involving atomic-level modification of molecular structure using bond formation advanced techniques of synthetic chemistry. (2) It draws from the enormous wealth of examples in biology for the development of complex, functional structures. (3) It can incorporate biological structures directly as components in the final systems. (4) It requires that the target self-assembled structures be thermodynamically most stable with relatively defect-free and self-healing. In this book, we cover the various emerging self-assembled nanostructured objects including molecular machines, nano-cars molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nano-flakes, nano-cubes, nano-disks, nanorings, DNA origami, transmembrane channels, and vesicles. These self-assembled materials are used for sensing, drug delivery, molecular recognition, tissue engineering energy generation, and molecular tuning.
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Table of Contents
1. An introduction of self-assembled nanobiomaterials and their applications2. Design and construction of bioinspired supramolecular self-assembled nanostructures3. Design and construction of amino acids, peptides and proteins-based self-assembled nanostructures4. Recent development in chiral self-assembly of porphyrin and protoporphyrin IX molecular architectures5. Design and construction of arlene diimide based self-assembled nanostructures6. Self-assembled functional materials of aggregation-induced emission active molecules7. Design and construction of amphiphilic and bolaamphiphilic material based self-assembled micellar nanostructures 8. Self-assembled living materials and their applications9. 3D bioprinting: overview and recent developments10. Self-assembled peptides and proteins for biomedical applications11. Design and construction of protein and peptide-based self-assembled nanostructures12. Self-assembled nanomaterials for drug delivery13. Carbon nanotubes and graphene nanomaterials for biomedical applications14. DNA/RNA-based self-assemblies for bio-sensing15. Self-assembled nanomaterials for cleansing and bioremediation16. Bio-interfacial DNA self-assemblies for biomedical applications17. DNA nanodevices in nanomedicine and therapeuticsAuthors
Alok Pandya School of Applied of Science and Technology, Gujarat Technological technology, Ahmedabad. Dr. Alok Pandya is an innovator, interdisciplinary researcher, and academic leader specializing in the development of personalized biosensors for point-of-care/need diagnostics and rapid disease detection. His work focuses on developing advanced biosensing technologies for real-time health monitoring. Currently serving as an Associate Professor at the School of Applied Science and Technology, Gujarat Technological University, he brings over 11 years of research experience dedicated to biosensor-driven rapid diagnostics. Before joining GTU, Dr. Pandya spent 8 years as an Assistant Professor at the Institute of Advanced Research (IAR) and 3 years as a Research Associate at Ahmedabad University. He has also been a Visiting Professor at the University of California, San Diego, conducting research on wearable biosensors, and an Entrepreneurial Lead under the US National Science Foundation's I-CorpsT program, gaining expertise in medical innovation and technology commercialization. A researcher and technologist, Dr. Pandya has published 60+ research articles, authored 5 books & 12+ book chapters, and holds 5 granted patents. His work has secured national and international funding to advance biomedical and forensic diagnostic technologies. He has been honored with prestigious awards, including the SERB-International Research Experience Award, the SERB Young Scientist Award, and the IAR Research Excellence Award. Dr. Pandya has developed cutting-edge biosensing platforms for rapid AMR detection, cardiovascular disease diagnostics, plant pathogen identification, and forensic body fluid analysis. With global research collaborations spanning France, the USA, and India, Dr. Pandya continues to drive innovation in biosensor technology, translating scientific discoveries into real-world applications for precision diagnostics and personalized healthcare. Rajesh S. Bhosale Associate Professor, Department of Chemistry, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India. Dr. Rajesh S. Bhosale is an Associate Professor at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He did his PhD (2009) from University of Geneva (Switzerland) under the supervision of Prof. Stefan Matile. Thereafter, he did first post-doctoral research as SNSF postdoctoral fellow from top institutes of World i.e. MIT-Massachusetts Institute of Technology, Cambridge, USA in the group of Prof. Timothy M. Swager and second post-doctoral research as DFG postdoctoral fellow from FRIAS-Freiburg Institute for Advanced Studies, Germany in the group of Prof. Aurelio Mateo-alonso. Where he was excelled in challenging multistep chemical synthesis, electrochemical, photophysical and self-assembly properties study of small molecules, macromolecules and polymer chromophoric systems. He also served as RMIT research associate in the group of Prof. M. Lakshmi Kantam at CSIR-IICT, Hyderabad and in July 2015 he becomes a CSIR scientist pool officer. His research interests are focused on building AIE active novel molecules. Vijai Singh Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India.Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.
