Osmolytes and Intrinsically Disordered Proteins: From Functional Regulation to Disease Pathogenesis, Volume 112 delves into the fascinating interplay between osmolytes and intrinsically disordered proteins (IDPs), exploring their pivotal roles in cellular function and disease mechanisms. This volume brings together experts to present cutting-edge research on how osmolytes regulate functional behavior of IDPs and ensure cellular stability and adaptability under stress conditions. Specific chapters cover Functional diversity of IDPs and their structural heterogeneity: Protein structure-function continuum, Osmolytes as structure-function regulators of intrinsically disordered casein, Synergism of the effects of osmolytes and crowders on structure and function of IDPs/IDRs: The natural habitat, and more.
Additional chapters delve into Osmolyte-IDP Interactions during Desiccation, Modulation of aggregation/fibrillation propensity of IDPs by osmolytes, Osmolytes in modulating the structural and functional integrity of a-synuclein: a study based on Parkinson's disease, Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes, Aggregation and inhibitory strategies of amyloid fibrillation, and much more.
Additional chapters delve into Osmolyte-IDP Interactions during Desiccation, Modulation of aggregation/fibrillation propensity of IDPs by osmolytes, Osmolytes in modulating the structural and functional integrity of a-synuclein: a study based on Parkinson's disease, Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes, Aggregation and inhibitory strategies of amyloid fibrillation, and much more.
Table of Contents
1. Functional diversity of IDPs and their structural heterogeneity: Protein structure-function continuumVladimir N. Uversky
2. Osmolytes as structure-function regulators of intrinsically disordered casein
Mohd. Younus Bhat
3. Synergism of the effects of osmolytes and crowders on structure and function of IDPs/IDRs: The natural habitat
Terrence G. Oas
4. Osmolyte-IDP Interactions during Desiccation
Vincent Nicholson, Thomas Boothby and Emma K. Meese
5. Modulation of aggregation/fibrillation propensity of IDPs by osmolytes
Tanveer Ali Dar Sr.
6. Osmolytes in modulating the structural and functional integrity of a-synuclein: a study based on Parkinson's disease
Laishram R. Singh
7. Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes.
Alice Y. Liu, Amala Mathew, Christopher Karim, Pierre Eshak and Kuang Yu Chen
8. Md Nadir Hassan, Murtaza Hussain, Rizwan Hasan Khan, Aggregation and inhibitory strategies of amyloid fibrillation
Rizwan Hasan Khan and Rizwan H. Khan
9. Modulation of amyloid beta and Tau aggregation by Phytochemicals: Implications in Alzheimer’s Disease
Mohd. Kamil Hussain, Shakir Ahamad, Moazzam Ahmad, Mohammad Saquib, Shahnaaz Khatoon, Karam Fatima and Mohsin Vahid Khan
10. The Emerging Landscape of Natural Small-molecule Therapeutics for Huntington’s Disease
Shahnawaz Ali Bhat, Shakir Ahamad, Sameera Khan and Nargis Bano
11. Molecular crowding and amyloidogenic self-assembly: emergent perspectives from modern computations
Neelanjana Sengupta
