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Biliary Tract Neoplasms

  • Book

  • September 2025
  • Elsevier Science and Technology
  • ID: 6057639
Biliary Tract Neoplasms is a state-of-art reference of the multimodality management of bile duct cancer written by leaders in the field. As targeted therapy and clinical trials in this field are exploding, and the incidence of the disease is increasing, now is the time to address the topic in practical manner. This reference addresses surgical approaches to biliary neoplasms, targeted personalized systemic approaches to biliary neoplasms, and other treatment modalities such as radiotherapy and ablation. It is intended for scientists, researchers, clinicians, practicing surgeons, surgical oncologists, transplant surgeons as well as fellows/residents in the surgical space.

The book's translational nature and impact of basic science findings that have informed targeted therapy for biliary neoplasms provide the very latest data on surgery, medical, imaging, and multi-modality care of biliary neoplasm to educate and inform care of this patient population.

Table of Contents

1. Epidemiology
2. Risk Factors and Clinical Presentation of BTC
3. Radiologic Presentation of BTC
4. Pathologic Classification and Staging of BTC
5. Biliary Tract Decompression
6. Surgical Resection for Cholangiocarcinoma
7. Surgical Resection for Gallbladder Cancer
8. Systemic Therapy for BTC
9. Targeted Therapy for BTC
10. Optimizing Immunotherapy for BTC
11. Radiation therapy for BTC
12. Liver Directed Therapy
13. Sequencing of therapy
14. Evolving role of Transplantation
15. The Clinical Trials Landscape The Future of BTC

Authors

Timothy M. Pawlik Professor and Chair, Department of Surgery, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, Professor of Surgery, Oncology, and Health Services Management and Policy, Surgeon in Chief, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Dr. Timothy M. Pawlik received his undergraduate degree from Georgetown University and his medical degree from Tufts University School of Medicine. Dr. Pawlik completed surgical training at the University of Michigan Hospital and spent two years at the Massachusetts General Hospital as a surgical oncology research fellow. He then went on to advanced training in surgical oncology at The University of Texas M. D. Anderson Cancer Center in Houston. Dr. Pawlik's main clinical interests include alimentary tract surgery, with a special interest in hepatic, pancreatic and biliary diseases. Dr. Pawlik has also completed a fellowship in medical ethics at the Harvard School of Public Health, as well as a Masters in Theology from Harvard Divinity School, Boston. In addition, Dr. Pawlik received a PhD from the Johns Hopkins Bloomberg School of Public Health in Clinical Investigations. Dr. Pawlik also received his Executive MBA Program from The Ohio State University Fisher Business School. Dr. Pawlik is the Chair of Surgery at The Ohio State University Wexner Medical Center where he holds The Urban Meyer III and Shelley Meyer Chair for Cancer Research. Dr. Pawlik is a past-President of the Association for Academic Surgery, past-President of the Americas Hepato-Pancreato-Biliary Association, co-President of the Surgical Biology II Club, as well as current President of the Association for Academic Surgery Foundation. Dr. Pawlik's research focuses on determinations of factors associated with prognosis and staging of gastrointestinal cancers, as well as the economics of cancer care. He also studied patient/physician communication and patient engagement, as well as patient perception of cancer-care goals and the impact of social determinants of health.

Shishir K. Maithel Professor, Division of Surgical Oncology, Department of Surgery of Emory University School of Medicine, USA.

Dr. Shishir K. Maithel, MD, FACS, FSSO is Professor of Surgery and Chief of the Division of Surgical Oncology and Chief Surgical Oncology Officer of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Feinberg School of Medicine. His clinical and research interests focus on tumors of the bile ducts, as well as other gastrointestinal malignancies such as cancer of the liver, pancreas, stomach, colon, and small intestine. He is an active member of the Cholangiocarcinoma Foundation and is leading the effort in running novel clinical trials for patients with early-stage biliary cancers.