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Activase (Alteplase) is a thrombolytic drug used to treat acute ischemic stroke, acute myocardial infarction, and pulmonary embolism. It is a recombinant form of tissue plasminogen activator (tPA), a naturally occurring enzyme that helps dissolve blood clots. Activase works by breaking down the clot, restoring blood flow to the affected area, and preventing further damage. It is the only FDA-approved thrombolytic drug for the treatment of acute ischemic stroke.
Activase is a key component of cardiovascular drug therapy, as it can help reduce the risk of death and disability associated with stroke, heart attack, and pulmonary embolism. It is also used to treat deep vein thrombosis, a condition in which a blood clot forms in a deep vein. Activase is administered intravenously, and its effects can be seen within minutes.
The Activase market is highly competitive, with several major pharmaceutical companies offering their own versions of the drug. These include Genentech, Boehringer Ingelheim, Pfizer, and Sanofi. Other companies, such as Merck, Novartis, and AstraZeneca, also offer generic versions of Activase. Show Less Read more